Comparative therapeutic efficiency between phenylbutazone and dexamethasone in chicks

Abstract

The current objective was to compare the antiinflammatory, analgesic, and antipyretic efficiency of phenylbutazone (PBZ) in contrast to dexamethasone (DMZ) in 7-15 days-old chicks. The analgesic ED50 value of PBZ and DMZ  given alone were 5.60 and 0.63  mg/kg, i.p. PBZ and DMZ analgesic percentages were the same in the chicks while PBZ had a significantly more potent analgesic effects in comparison to DMZ regarding the post voltage of analgesia measured beside there is a significant value related to the pre and post-voltage measured in the PBZ group. Baker’s yeast induces a significant pyresis 3 hour after its injection. PBZ gives rise to its significant antipyretic activity at 2, 3 and 4 hours after pyretic induction by baker’s yeast while DMZ illustrates its antipyretic significantly at 4 hours of measured time. PBZ and DMZ exert their anti-inflammatory activity by 71 and 57%, respectively. PBZ and DMZ have a significant anti-inflammatory property through a significant reduction in delta-thickness in comparison to the control group besides the supremacy of PBZ over DMZ. Both PBZ and DMZ treatment for five consecutive days in the chicks have no significant difference in the concentrations of creatinine and uric acid (kidney function) besides AST and ALT (liver function) in comparison to the control group except the significant elevation in the creatinine concentration at the PBZ group. The net results of this comparative study indicated that PBZ has good, reliable and profound antiinflammatory, analgesic, and antipyretic efficiency than DMZ of the chickens model.