Protective Effect of Ocimum Tenuiflorum Against Negative Effect Filgrastim on Sperm Parameters of Male Rats

Abstract

Filgrastim is an anticancer drug used for the treatment of cancer patients that suffering neutropenia, on the last years found filgrastim has an adverse effect and wreak lesion on different organs as testis that attributed to formation reactive oxygen species. In general, the last studies suggested to used natural substance beside the anticancer drug for decreased the reactive oxygen species as well as curcumins and lycopene. The Ocimum tenuiflorum generally used as antiinflammation and antioxidant, thus our study aimed for evolution the productive effect of Ocimum tenuiflorum against filgrastim. In the study 40 male rats was used and divided in 4 equal groups which the 1st  group was intraperitoneal injected of 30.83 mcg/kg/day of Filgrastim for one week, the 2nd  group that treated with of Ocimum basilicum suspended in corn oil and administered by gavage at 20 mg/kg for 2 week, while the 3rd group that rats was intraperitoneal injected of 30.83 mcg/kg/day of Filgrastim for one week beside that treated with Ocimum tenuiflorum group and finally the 4th  group treated with placebo, than, after 40 days of experiment, evaluation of sperm parameters. In conclusion our result proved that Ocimum tenuiflorum has productive effect against adverse of filgrastim.