Ameliorative Impact of Some Anti-Stressful Agents in Broilers Exposed to Dexamethasone as a Stress Model

  • Hala O. A. Al-sharhan, Hiyam N. Maty

Abstract

Our study was intended to know the effectiveness of sodium butyrate and betaine as anti-stressful agents when added as a feed additive to boilers exposed to dexamethasone. 96 broilers were divided into four treatments, each having 24 broilers, three replications, and two age groups of 21 and 42 days. The control was GC, whereas DEX was given at three-day intervals in GD (Dosage: 1mg/kg B.W S/C) the dosage was evaluated following the preliminary study, then GS was injected with DEX at three-day intervals and was given sodium butyrate (Dosage: 1.2 g/kg feed), finally, GB has given DEX injections every three days and betaine (Dosage: 2 g/kg feed). The results revealed that at 21 days of age the GD that suffered from oxidative stress statically has the highest levels of MDA with an increase in HSP90 in serum, spleen and bursa, and the lowest values of GSH in serum, spleen and bursa, while the feed supplementation with sodium butyrate and betaine gave their effects to cope the oxidative stress in boilers and this reflected in the parameters which implode HSP90 and stress biomarkers that showed statically raising in GSH levels in serum, and bursa except spleen with a decrease in HSP90 and falling in MDA values in serum, spleen and bursa. At 42 days of age observed approximately the same results when compared with control except no statically different of GSH in serum when treated with betaine. We concluded that dietary sodium butyrate and betaine were successfully used as anti-stressful agents.

Published
2022-06-29
How to Cite
Hiyam N. Maty, H. O. A. A.- sharhan,. (2022). Ameliorative Impact of Some Anti-Stressful Agents in Broilers Exposed to Dexamethasone as a Stress Model. Revista Electronica De Veterinaria, 227 - 237. Retrieved from https://veterinaria.org/index.php/REDVET/article/view/206