The Protective Effect of Coenzyme Q10 against Doxorubicin-induced Nephrotoxicity in Albino Rats
Despite the fact that doxorubicin (Dox) is effective anticancer chemotherapy, it has a number of adverse effects, including nephrotoxicity, which limits its clinical value. The present study aimed to investigate the potential protective effect of coenzyme-Q10 (CoQ10) on Dox-induced nephrotoxicity. Male albino rats were pretreated with either 10 mg/kg of CoQ10 or placebo for 17 days, and on day 13 of the experiment, some of the rats were either given a single 15 mg/kg injection of Dox or normal saline into the peritoneum. Serum urea and creatinine were measured. A full histopathological examination was performed on the kidney. Dox caused significant elevation of serum urea and creatinine levels. CoQ10 was able to inhibit the elevation of these renal function tests. According to histopathological inspection, the control and CoQ10 groups exhibited normal renal glomeruli, Bowman's space, and renal tubule architecture. However, Dox-treatment caused glomerular atrophy, dilated Bowman's space, renal cyst, hemorrhage, blood vessel congestion, infiltration of inflammatory cells, and significant degeneration and necrosis of renal tubules. Pretreatment with CoQ10 resulted in considerable inhibition of the histological nephrotoxic effects of Dox. It is concluded that pre-treatment with CoQ10 can have a protective role against Dox-induced nephrotoxicity via, at least partially, preserving the normal histological architecture of the kidney.Supplementation with CoQ10 is important for Dox-treated individuals.