Investigation of Potassium Dichromate Nephrotoxicity in Association with Vitamin C in Rate
Objective : Heavy metal poisoning in the environment has attracted a lot of interest in previous years. Hexavalent chromium is because it is widely used in various industrial uses, the goal of this study is to see how potassium dichromate affects renal tubules and to assessment of Vitamin C's Function as protective agent the effects of heavy metal (Potassium dichromate).
Materials and Methods : Male rates of the study were divided into three groups. Each group consists of 10 male rats used for the design experiments as the following ( G1 control group , G2 received a dose of 1ml intraperitoneally of 2 mg/kg of body weight per day of potassium dichromate and G3 received both of the vitamin C in a dosage of 1ml in a concentration of 2mg/kg and potassium dichromate in a dose of 1ml in a concentration of 2mg/kg per day for 14 days and then they going to sacrificing and Histopathological examination
Results : Control group had normal glomerular and tubular histology in both the cortical and medullary areas of their kidneys, G2 Potassium dichromate-treated rats showed necrosis of most convoluted tubules in the cortex; G3 pre-treted Potassium dichromate-treated rats showed little histological changes of most convoluted tubules in the cortex.
Conclusions : The result indicated the role of chromium compounds' toxicity in the induction of harmful effects in renal tissue and the protective role of ascorbic acid in decreasing these tissue changes.