Study Some Biochemical Parameters in Serum and Bone of Adults Female Rats Treated with Normal Omega-3 Fatty Acids
Bone diseases are increasingly reported as a challenging dilemma in a health care setting, due to limited therapeutic options, slow response of bone diseases to therapy and long-term needs to induce effects. Omega-3 Fatty acids (ꞷ3FA) have recently been introduced in the treatment of some bone diseases mainly as adjuvant therapy. Herein we explored the potential therapeutic effects of ꞷ3FA on bone formation and resorption in adult female rats if any. To do so, serum samples were collected from rats treated with ꞷ3FA versus the control group and the serum was analysed for determination of the levels of “vitamin D, IGF-1, Alkaline phosphatase activity, Calcium, Phosphorus and Albumin” alongside femur bones were collected for bone ash study of rats treated with ꞷ3FA versus a control group. Results showed a significant increase in vitamin D, Calcium, Phosphorus, and albumin and a significant reduction in alkaline phosphatase activity, Insulin-like growth factor-1 (IGF-1) in a group which gave 20 mg/kg of ꞷ3FA compared to the control group, while treatment animals with 40 mg/kg of ꞷ3FA caused a significant reduction in vitamin D and Phosphorus also a significant increasing in IGF-1, Alkaline phosphatase activity, and Albumin. Also, there was a significant increase in calcium and phosphorus content in bone ash of the group which took 20 mg/kg ꞷ3FA while these contents were reduced in bone ash of the group taking 40 mg/kg ꞷ3FA.