Study the Effects of Anadrol Overdose on Kidney in Rat Model
Background: This study intends to research nephrotoxicity of anadrol through evaluation of renal injury markers and histopathological study. Materials and techniques: A forty male rodents, loads around (200-300 gm), matured 8-12 weeks, after acclimatization, the rodents were randomly partitioned into four gatherings (n=10) : control bunch (in which all rodents were regulated typical saline (NS) by means of oral gavage), anadrol 10 mg/kg bunch (in which all rodents were directed anadrol 10mg/kg through oral gavage), anadrol 20 mg/kg bunch (in which all rodents were managed anadrol 20mg/kg by means of oral gavage), and anadrol 30 mg/kg bunch (in which all rodents were managed anadrol 30mg/kg by means of oral gavage), the oral organization had gone on for a considerable length of time. Toward the finish of study urea and creatinine were estimated through compound examination. Then, at that point, renal histopathological study was finished.
Results: Rats treated with anadrol showed elevated degree of urea and creatinine, as contrasted and control bunch. Then again, histopathological concentrate on showed huge damaging changes in the renal tissue in anadrol bunches contrasting and control.
End: When given in high dosages anadrol brings about renal injury, that can be cleared by means of both raised degrees of renal injury markers and renal histopathological changes.