Ischemic Post Conditioning Prevents Preterm Cell Death in Rats

  • Shivangi Lecturer, Department of Pharmacy, Usha Martin University, Ranchi, Jharkhand
  • Brishnendra Mishra Assistant Professor, Department of Pharmacy, Himalayan University, Itanagar-Arunachal Pradesh
  • Sushant Kumar Sharma Assistant Professor, Department of Pharmacy, Mangalayatan University, Aligarh, Uttar Pradesh
  • Tashi Choden Lepcha Assistant Professor, Collage of Pharmacy, Sikkim Professional University, Gangtok, Sikkim
Keywords: Stroke, Cerebral injury, early cell death, Ischemic postconditioning


Ischemic postconditioning, also known as Postcond, is a sequence of periodic blood flow disruptions that happen in the beginning phases of reperfusion and affect the hydrodynamics of reperfusion. Current research reveals that Postcond lessens the severity of infarcts, which in turn lessens the impact of cerebral ischemia/reperfusion (I/R) damage. The paths of Postcond I/R damage are, however, poorly known. The goal of this research was to evaluate Postcond's effects on I/R damage with blocked arteries of brain. Adult were occluded for 60 minutes before receiving postconversion therapy (beginning of reperfusion). At 24 and 72 hours, infarct dimensions and neurologic state were evaluated. Malondialdehyde test was used to quantify oxidative stress, and Western blotting was used to identify substances linked to apoptosis. Following postmortem treatment, the expression of protein increased, but cyt c levels in cytsol dropped, was not activated. Infarct diameters, oxidative stress, and neurologic ratings were decreased with Postcond therapy results imply induced brain damage.


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How to Cite
Shivangi, Brishnendra Mishra, Sushant Kumar Sharma, & Tashi Choden Lepcha. (2022). Ischemic Post Conditioning Prevents Preterm Cell Death in Rats. Revista Electronica De Veterinaria, 23(4), 41 - 46. Retrieved from