Efficiency of Purified Biosurfactant (Pseudofactin) from P. Aeruginosa in Disruption of Biofilm Formation by Candida Albicans in Vaginal Candidiasis

  • Raghda Zakaria Muttlak Department of Pharmacy, Al-Hadba University College, Iraq
  • Mohammed Abdul Hadi Al-Farahidi University, Medical Lab. Techniques department, College of Medical Technology, Iraq
  • Mohammed Abed Jawad Department of Medical Laboratories Technology, Al-Nisour University College, Iraq
  • Sara Hameed Thejeel National University of Science and Technology, Dhi Qar, Iraq
  • Zainab H. A. Department of Pharmacy, Al-Zahrawi University College, Karbala, Iraq
Keywords: Pseudomonas aeruginosa, biosurfactant, vaginal candidiasis


Candidiasis caused by Candida albicans is one of the most common forms of hospital-acquired opportunistic infection. So that the biosurfactant was detected in P. aeruginosa isolated from burns and wounds infections and produced with different levels of productivity. The use of (2:1) of chloroform: acetone was the best for extraction of biosurfactant with 11.3 g/l while chloroform: propanol gave a low yield of 2.41 g/l of biosurfactant. Candida albicans causing vaginal candidiasis considered a stronger producer of biofilms. The effect of biosurfactant on Candida biofilm formation was inhibited with increasing incubation period and the percentage of biofilm inhibition reached 45-78% after 24 hours and increased to 65-84% after 48 hours.


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How to Cite
Raghda Zakaria Muttlak, Mohammed Abdul Hadi, Mohammed Abed Jawad, Sara Hameed Thejeel, & Zainab H. A. (2023). Efficiency of Purified Biosurfactant (Pseudofactin) from P. Aeruginosa in Disruption of Biofilm Formation by Candida Albicans in Vaginal Candidiasis. Revista Electronica De Veterinaria, 24(1), 54 - 61. Retrieved from https://veterinaria.org/index.php/REDVET/article/view/300