Investigating the Potential Reversibility of Trimetion-Induced Testicular Histopathological Changes in Male Rabbits

Abstract

This investigation examining the testicles, epididymis, and ovulation of male adults bunnies used Trimetion poisoning to cause pathologic lesions. A grand total of 50 native masculine rabbits were obtained, trained, and randomly assigned to one of four categories: the group with no treatment (control group (CG)), the 10 ml/Kg Trimetion the group (G-I), the 25 ml/Kg Trimetion the group (G-II), and the 50 ml/Kg Trimetion the group (G-III), all of which were administered orally over the course of 70 days. The testicles of the groups receiving treatment were smaller than those of the untreated group. Trimetion induces dose-dependent harm to the testicles, as demonstrated by minor hydropic deterioration, shedding of cells interior, and substantial reduction of sperm production in control group; whereas in GI, the bladder seems to be devoid of males. These findings were shown by the main histological lesions of soaked bunnies. Despite limited hydropic deterioration, spermatogonial restriction, and a significant absence of sperm formation, testicles injury was greater in G-II. Every testicles displayed violent, serious, and extensive spots, as well as significant necrotic and complete spermatogonial inhibition without any spermatozoa according to the results of G-III. The present research concluded by demonstrating that Trimetion is produced by various diseases in the masculine testicles and epididymal materials of mature bunnies, that displayed microscope severe apoptosis and degenerations and completely suppressed sperm production with sperm cells vacuolation. Yet, additional research is needed to pinpoint additional toxicopathological alterations in other bodily tissues.