Exploring the Antifungal Properties of Steroidal Saponins: An In-Depth Analysis

  • Mukesh Singh Sikarwar Professor, College Of Pharmacy, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, India
  • Nayana Borah Assistant Professor, Department of Life Science, School of Sciences, JAIN (Deemed-to-be University), Karnataka, India
  • Manoj Rameshachandra Vyas Professor, Department of Ayurveda, Sanskriti University, Mathura, Uttar Pradesh, India
Keywords: Pathogens, Saponins, Fungal infections, Antifungal activity


Scientific investigation and study have focused on the antifungal characteristics of steroidal saponins. Numerous researches have looked into the ability of steroidal saponins to reduce the activity and growth of certain fungi. A variety of fungal infections, such as Candida species, Aspergillus species, Cryptococcus neoformans, Trichophyton species, and others, has been shown to be inhibited by steroidal saponins. We examined how well six steroidal sapogenins and twenty-two steroidal saponins C-27 affected the four prevalent opportunistic infections Candida species, Aspergillus species, and Cryptococcus species. It has been found that a certain type of saccharide is connected to the antifungal activities of steroidal saponins. Four of the 10 steroidal compounds in total had activity comparable to the positive control. These compounds' cytotoxicity towards mammalian cells was separate from their antifungal activity. Preclinical research is made possible by the potential antifungal properties of Carbon-27 steroidal saponins. Steroid saponins' antifungal properties are thought to be mediated by a number of different mechanisms. According to certain research, steroidal saponins break the fungal cell membrane, causing the membrane to become permeable and allow cellular components to flow out. This interference may hinder fungal vitality and growth. Other hypothesised methods include inhibiting fungal enzymes and interfering with the formation of fungal cell walls.


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How to Cite
Mukesh Singh Sikarwar, Nayana Borah, & Manoj Rameshachandra Vyas. (2023). Exploring the Antifungal Properties of Steroidal Saponins: An In-Depth Analysis. Revista Electronica De Veterinaria, 24(2), 38 - 46. Retrieved from https://veterinaria.org/index.php/REDVET/article/view/325