Exploring the Antifungal Properties of Steroidal Saponins: An In-Depth Analysis
Scientific investigation and study have focused on the antifungal characteristics of steroidal saponins. Numerous researches have looked into the ability of steroidal saponins to reduce the activity and growth of certain fungi. A variety of fungal infections, such as Candida species, Aspergillus species, Cryptococcus neoformans, Trichophyton species, and others, has been shown to be inhibited by steroidal saponins. We examined how well six steroidal sapogenins and twenty-two steroidal saponins C-27 affected the four prevalent opportunistic infections Candida species, Aspergillus species, and Cryptococcus species. It has been found that a certain type of saccharide is connected to the antifungal activities of steroidal saponins. Four of the 10 steroidal compounds in total had activity comparable to the positive control. These compounds' cytotoxicity towards mammalian cells was separate from their antifungal activity. Preclinical research is made possible by the potential antifungal properties of Carbon-27 steroidal saponins. Steroid saponins' antifungal properties are thought to be mediated by a number of different mechanisms. According to certain research, steroidal saponins break the fungal cell membrane, causing the membrane to become permeable and allow cellular components to flow out. This interference may hinder fungal vitality and growth. Other hypothesised methods include inhibiting fungal enzymes and interfering with the formation of fungal cell walls.
Nguyen, L.T., Farcas, A.C., Socaci, S.A., Tofana, M., Diaconeasa, Z.M., Pop, O.L. and Salanta, L.C., 2020. An overview of Saponins–a bioactive group. Bulletin UASVM Food Science and Technology, 77(1), pp.25-36.
Li, Y., Yang, H., Li, Z., Li, S. and Li, J., 2023. Advances in the Biosynthesis and Molecular Evolution of Steroidal Saponins in Plants. International Journal of Molecular Sciences, 24(3), p.2620.
Morcia, C., Piazza, I., Ghizzoni, R., Delbono, S., Felici, B., Baima, S., Scossa, F., Biazzi, E., Tava, A., Terzi, V. and Finocchiaro, F., 2022. In Search of Antifungals from the Plant World: The Potential of Saponins and Brassica Species against Verticillium dahliae Kleb. Horticulturae, 8(8), p.729.
Liu, W., Sun, B., Yang, M., Zhang, Z., Zhang, X., Pang, T. and Wang, S., 2019. Antifungal activity of crude extract from the rhizome and root of Smilacina japonica A. Gray. Evidence-Based Complementary and Alternative Medicine, 2019.
Porte, S., Joshi, V., Shah, K. and Chauhan, N.S., 2022. Plants' steroidal saponins-A review of its pharmacology properties and analytical techniques. World Journal of Traditional Chinese Medicine, 8(3), p.350.
Orczyk, M., Wojciechowski, K. and Brezesinski, G., 2020. The influence of steroidal and triterpenoid saponins on monolayer models of the outer leaflets of human erythrocytes, E. coli, and S. cerevisiae cell membranes. Journal of colloid and interface science, 563, pp.207-217.
Juang, Y.P. and Liang, P.H., 2020. Biological and pharmacological effects of synthetic saponins. Molecules, 25(21), p.4974.
Passos, F.R.S., Araújo-Filho, H.G., Monteiro, B.S., Shanmugam, S., de Souza Araújo, A.A., da Silva Almeida, J.R.G., Thangaraj, P., Júnior, L.J.Q. and Quintans, J.D.S.S., 2022. Anti-inflammatory and modulatory effects of steroidal saponins and sapogenins on cytokines: A review of pre-clinical research. Phytomedicine, 96, p.153842.
Sobolewska, D., Galanty, A., Grabowska, K., Makowska-Wąs, J., Wróbel-Biedrawa, D. and Podolak, I., 2020. Saponins as cytotoxic agents: an update (2010–2018). Part I—steroidal saponins. Phytochemistry reviews, 19, pp.139-189.
Zhao, D., Yan, J., Shi, X., Sun, Z., Xie, H., Wang, B., Jin, Y., and Li, X., 2023. Steroidal saponins from the roots of Polygonatum odoratum and their inhibitory effects against pancreatic lipase. Phytochemistry Letters, 53, pp.202-210.
Majnooni, M.B., Fakhri, S., Ghanadian, S.M., Bahrami, G., Mansouri, K., Iranpanah, A., Farzaei, M.H. and Mojarrab, M., 2023. Inhibiting Angiogenesis by Anti-Cancer Saponins: From Phytochemistry to Cellular Signaling Pathways. Metabolites, 13(3), p.323.
Valencia-Mejía, E., León-Wilchez, Y.Y., Monribot-Villanueva, J.L., Ramírez-Vázquez, M., Bonilla-Landa, I. and Guerrero-Analco, J.A., 2022. Isolation and identification of pennogenin tetra glycoside from Cestrum nocturnum (Solanaceae) and Its antifungal activity against Fusarium kuroshium, the causal agent of Fusarium Dieback. Molecules, 27(6), p.1860.
Alghirani, M.M., Chung, E.L.T., Jesse, A., Firdaus, F., Sazili, A.Q. and Loh, T.C., 2022. The Potential Use of Plant-Derived Saponins as a Phytobiotic Additive in Poultry Feed for Production and Health Advancement: A Comprehensive Review. Poultry Science Journal, 10(2).
Amaha, N.D., Mebrahtu, S.G. and Abdu, N., 2022. Saponins and their synergistic antibacterial activity with traditional antibiotics against Staphylococcus aureus and Escherichia coli. Qeios.
Morcia, C., Piazza, I., Ghizzoni, R., Delbono, S., Felici, B., Baima, S., Scossa, F., Biazzi, E., Tava, A. and Terzi, V., 2022. In Search of Antifungals from the Plant World: The Potential of Saponins and Brassica Species against Verticillium dahliae Kleb. Horticulturae 2022, 8, 729.
Samanta, R., Pandey, A., Bhardwaj, P. and Subba, B., 2022. The Studies of Antifungal Properties of Steroidal Saponin. Revista Electronica de Veterinaria, 23(4), pp.35-40.
Thu, Z.M., Oo, S.M., Nwe, T.M., Aung, H.T., Armijos, C., Hussain, F.H. and Vidari, G., 2021. Structures and bioactivities of steroidal saponins isolated from the genera Dracaena and Sansevieria. Molecules, 26(7), p.1916.
Pereira, G.M. and Cruz, M.D.F.S.J., 2021. Therapeutic properties and structural characterization of steroidal saponins: a review.
Abdelrahman, M., Jogaiah, S., Abdelrahman, M. and Jogaiah, S., 2020. Production of plant bioactive triterpenoid and steroidal Saponins. Bioactive Molecules in Plant Defense: Saponins, pp.5-13.
Jiménez, G.G., Durán, A.G., Macías, F.A. and Simonet, A.M., 2021. Structure, bioactivity, and analytical methods for the determination of Yucca saponins. Molecules, 26(17), p.5251.