Preterm Cell Death Prevention in Rats with Ischemic Post Conditioning: An Experimental Study
Abstract
Ischemic post conditioning, also known as Postcond, occurs during the early stages of reperfusion as a series of periodic disturbances in blood flow that alter the fluid dynamics of reperfusion. Recent studies have shown that Postcond mitigates the effects of cerebral ischemia/reperfusion (I/R) damage by reducing the size of infarcts. However, the causes of Postcond I/R degradation are not understood. The purpose of this study was to determine the efficacy of Postcond in preventing brain I/R damage in the presence of blocked cerebral arteries. After 60 minutes of occlusion, adults began reperfusion (post-conversion treatment). The size of the infarct and the patient's neurological status were both measured at 24 and 72 hours. The level of oxidative stress was measured using the malondialdehyde assay, and apoptosis-related proteins were identified using Western blotting. Postmortem therapy boosted protein expression but inhibited cyt c activation by decreasing cyt c levels in cytsol. Postcond treatment data suggest produced brain injury by reducing infarct sizes, oxidative stress, and neurologic scores.
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