Protective Role of Vitamin C Pretreatment in Acute Nickel Nephrotoxicity in Mice

  • Phool Chandra Professor, College of Pharmacy, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, India
  • Roopashree Assistant Professor, Department of Chemistry, School of Sciences, JAIN (Deemed-to-be University), Karnataka, India
  • Kiran Nagar Professor, Department of Ayurveda, Sanskriti University, Mathura, Uttar Pradesh, India
Keywords: Necrosis, Vitamin C (VC), Nickel chloride (NiCl2), Nephrotoxicity, Mice, Renal failure (RF)


Pretreatment with Vitamin C (VC) has been identified as a viable therapeutic approach for reducing acute Nickel (Ni) Nephrotoxicity in mice. During oxidative stress and inflammation, the hazardous heavy metal Ni is known to cause Renal Failure (RF). This study was carried out to examine the preventative benefit of VC consumption and its effects on Ni-induced RF. This study used 60 lab mice weighing between 30 and 35 grams. After being weighed, 44 adapted mice were chosen from among the 58 male mice. Six experimental categories made up of eight mice each were created from these 44 animals. The 30-day course of medication for the lab mice was continued. This study revealed no substantial variations in the weights of the Renal System (RS) in mice that had previously received VC, but there was a significant increase in the weight of the RS in mice that had received Nickel Chloride (NiCl2) injections while compared with the controls and the sample that received VC orally. The mice's blood levels of urea, creatinine, and uric acid were able to rise concurrently. Although VC treatment can protect the RS from these NC poisons, this was supported by changes in the mice's renal tissues. According to the study, taking VC supplements may work as an antioxidant to shield renal and hematological components from deterioration.


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How to Cite
Phool Chandra, Roopashree, & Kiran Nagar. (2023). Protective Role of Vitamin C Pretreatment in Acute Nickel Nephrotoxicity in Mice. Revista Electronica De Veterinaria, 24(2), 67 - 80. Retrieved from