Metabolic Biomarker Alterations in a Rat Model of Artificial Sweetener Consumption: Implications for Human Health

  • Syam Bhargavan Professor, Department of Ayurveda, Sanskriti University, Mathura, Uttar Pradesh, India
  • Krishana Kumar Sharma Professor, College of Pharmacy, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, India
  • Suphiya Parveen Assistant Professor, Department of Genetics, School of Sciences, JAIN (Deemed-to-be University), Karnataka, India
Keywords: Minimal Density lipoprotein (MDL), Artificial sweeteners, Fasting blood sugar, Metabolism


Due to some variables, especially the rising incidence of being overweight and hyperglycemia, the consumption of NNS has risen significantly globally in recent years. The use of NNS has produced conflicting findings in studies; some data suggest that it leads to weight gain and arises in hunger, while others claim that it has a major impact on weight loss and diabetes management. Using an in vivo rat model, the goal of this investigation is to look at the effects of several sweeteners that are not nutritious, affecting physical size, fasting blood sugar, Overall cholesterol (OC), triglycerides (TC), Extremely Hard lipoprotein (EHL), and Minimal Density lipoprotein (MDL), as well as body weight. According to the findings, stevia caused the rat's weight to drop by 50 grams after eight weeks, whereas, in the other groups, it stayed essentially the same, except for sucrose (G1) and acesulfame-K (G6), which caused a noticeable weight gain. In every group, there was a general rise in LDL and (OC)and a fall in HDL. In terms of shedding pounds and regulating blood sugar levels while fasting, stevia (G2), Sucralose (G3), aspartame (G5), and saccharine (G4) were discovered to be the most advantageous. In addition, conflicting findings from several studies underscore the ambiguity around the impacts of NSS.


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How to Cite
Syam Bhargavan, Krishana Kumar Sharma, & Suphiya Parveen. (2023). Metabolic Biomarker Alterations in a Rat Model of Artificial Sweetener Consumption: Implications for Human Health. Revista Electronica De Veterinaria, 24(2), 106 - 114. Retrieved from