The Protective Role of Pachira Glabra Leaves in Preventing Ethanol-Induced Gastric Ulcer in Rats
Abstract
Gastric ulcers are a frequent gastrointestinal illness that may be brought on by several things, including alcohol usage. These ulcers can be very harmful to one's health. This investigation looked at the effectiveness of Pachira glabra leaves in preventing ethanol-induced stomach ulcers in rats. A significant number of individuals worldwide are negatively affected by the relatively common condition known as a gastric ulcer. Research on the phytochemistry of P. glabra leaf alcohol extract. Helicobacter pylori's anti-activity was demonstrated in vitro by PGLE. Additionally, the in vivo gastroprotective evaluation of PGLE at various doses, 100, 200, and 400 mg/kg against ethanol-induced ulceration, indicated a dose-dependent gastroprotection similar to omeprazole. Gastric lesions and histological alterations brought on by ethanol were reduced by PGLE. Intriguingly, PGLE demonstrated an anti-inflammatory effect by suppressing nuclear factor B and the pro-inflammatory enzyme cyclooxygenase-2 expression in the ulcer group. Additionally, it prevented apoptosis by raising Bcl-2 expression and lowering Bax expression, which in turn reduced the Bax/Bcl2 ratio and decreased caspase 3 production.
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