Antibiotics in Livestock Production: A Comprehensive Examination of Usage, Resistance, and Regulatory Imperatives for Enhanced Oversight

  • Pravesh Belwal, Prasanna Mathad, Jayashree M kudari
Keywords: Antimicrobial, Resistance, Livestock Production, Antibiotic Use, Animal

Abstract

Antibiotic resistance (ABR) is a worldwide well-being concern due to the widespread using antibiotics in livestock farming. India lacks information on antibiotic use and resistance due to insufficient surveillance. Addressing this issue immediately is crucial as people can contract resistant germs from food animals through their dietary system. The primary goal of this research is to evaluate the present situation of antibiotic consumption in livestock production, assess the rise of antibiotic resistance and recommend regulatory imperatives for more supervision. A systematic literature review was conducted, identifying 200 relevant studies from the PubMed and Google Scholar databases. Employing predetermined exclusion criteria such as language (English only), relevance to livestock production, deletion of duplicate publications and specificity to animal species, 20 researches were considered for comprehensive analysis. The results demonstrate the strong connection that exists between the use of antibiotics and the development of resistance in animals. In addition to highlighting the significance of finding a balance between production demands and the danger of resistance, the study reveals major variables causing antibiotic resistance. The study looks into ways to reduce the hazards of ABR and residues in livestock. The study emphasizes the significance of preventative actions for public health and encourages an integrative approach to animal production that takes into account both the requirements of production and the need to reduce antibiotic resistance.

References

Walia, K., Sharma, M., Vijay, S., &Shome, B. R. (2019). Understanding policy dilemmas around antibiotic use in food animals & offering potential solutions. The Indian journal of medical research, 149(2), 107. DOI:10.4103%2Fijmr.IJMR_2_18

Hosain, M. Z., Kabir, S. L., & Kamal, M. M. (2021). Antimicrobial uses for livestock production in developing countries. Veterinary World, 14(1), 210. DOI: 10.14202/vetworld.2021.210-221

Wu, Z. (2019). Antibiotic use and Antibiotic resistance in food-producing animals in China. DOI:10.1787/18156797

Zhu, D., Giles, M., Daniell, T., Neilson, R., & Yang, X. R. (2020). Does reduced usage of antibiotics in livestock production mitigate the spread of Antibiotic resistance in soil, earthworm guts, and the phyllosphere?. Environment international, 136, 105359.DOI: 10.1016/j.envint.2019.105359

Tian, M., He, X., Feng, Y., Wang, W., Chen, H., Gong, M., ...& van Eerde, A. (2021). Pollution by antibiotics and antimicrobial resistance in livestock and poultry manure in China, and countermeasures. Antibiotics, 10(5), 539. DOI:10.3390/antibiotics10050539

Mthembu, T. P., Zishiri, O. T., & El Zowalaty, M. E. (2019). Molecular detection of multidrug-resistant Salmonella isolated from livestock production systems in South Africa. Infection and drug resistance, 3537-3548. DOI: 10.2147/IDR.S211618

Oliveira, N. A., Gonçalves, B. L., Lee, S. H., Oliveira, C. A. F., &Corassin, C. H. (2020). Use of antibiotics in animal production and its impact on human health. J. Food Chem. Nanotechnol, 6, 40-47.

Pham-Duc, P., Cook, M. A., Cong-Hong, H., Nguyen-Thuy, H., Padungtod, P., Nguyen-Thi, H., & Dang-Xuan, S. (2019). Knowledge, attitudes and practices of livestock and aquaculture producers regarding antimicrobial use and resistance in Vietnam. Plos one, 14(9), e0223115.10.1371/journal.pone.0223115

Mikecz, O., Pica-Ciamarra, U., Felis, A., Nizeyimana, G., Okello, P., &Brunelli, C. (2020). Data on antimicrobial use in livestock: Lessons from Uganda. One Health, 10, 100165. DOI:10.1016/j.onehlt.2020.100165

Gemeda, B. A., Amenu, K., Magnusson, U., Dohoo, I., Hallenberg, G. S., Alemayehu, G., ...& Wieland, B. (2020). Antimicrobial use in extensive smallholder livestock farming systems in Ethiopia: knowledge, attitudes, and practices of livestock keepers. Frontiers in Veterinary Science, 7, 55.DOI:10.3389/fvets.2020.00055

Ju, H., Li, S., Xu, Y. J., Zhang, G., & Zhang, J. (2019). Intensive livestock production causing antibiotic pollution in the yinma river of northeast china. Water, 11(10), 2006. 10.3390/w11102006

Rajala-Schultz, P., Nødtvedt, A., Halasa, T., &Persson Waller, K. (2021). Prudent use of antibiotics in dairy cows: The Nordic approach to udder health. Frontiers in Veterinary Science, 8, 623998.10.3389/fvets.2021.623998

Adegbeye, M. J., Elghandour, M. M., Faniyi, T. O., Rivero Perez, N., Barbabosa-Pilego, A., Zaragoza-Bastida, A., & Salem, A. Z. (2020). Antimicrobial and antihelminthic impacts of black cumin, pawpaw and mustard seeds in livestock production and health. Agroforestry Systems, 94, 1255-1268.DOI: 10.1007/s10457-018-0337-0

Zhu, Q., Sun, P., Zhang, B., Kong, L., Xiao, C., & Song, Z. (2021). Progress on gut health maintenance and antibiotic alternatives in broiler chicken production. Frontiers in Nutrition, 8, 692839.DOI: 10.3389/fnut.2021.692839

Beni, N. N., Snow, D. D., Berry, E. D., Mittelstet, A. R., Messer, T. L., &Bartelt-Hunt, S. (2020). Measuring the occurrence of antibiotics in surface water adjacent to cattle grazing areas using passive samplers. Science of the Total Environment, 726, 138296. DOI:10.1016/j.scitotenv.2020.138296

Xia, J., Ge, C., & Yao, H. (2021). Antimicrobial peptides from black soldier fly (Hermetiaillucens) as potential antimicrobial factors representing an alternative to antibiotics in livestock farming. Animals, 11(7), 1937.DOI: 10.3390/ani11071937

Lekagul, A., Tangcharoensathien, V., Liverani, M., Mills, A., Rushton, J., &Yeung, S. (2021). Understanding antibiotic use for pig farming in Thailand: a qualitative study. Antimicrobial Resistance & Infection Control, 10(1), 1-11. DOI: 10.1186/s13756-020-00865-9

Busch, G., Kassas, B., Palma, M. A., &Risius, A. (2020). Perceptions of antibiotic use in livestock farming in Germany, Italy and the United States. Livestock Science, 241, 104251. DOI: 10.1016/j.livsci.2020.104251

Callaway, T. R., Lillehoj, H., Chuanchuen, R., & Gay, C. G. (2021). Alternatives to antibiotics: A symposium on the challenges and solutions for animal health and production. DOI: 10.3390/antibiotics10050471

Zhao, Y., Yang, Q. E., Zhou, X., Wang, F. H., Muurinen, J., Virta, M. P., ...& Zhu, Y. G. (2021). Antibiotic resistome in the livestock and aquaculture industries: Status and solutions. Critical Reviews in Environmental Science and Technology, 51(19), 2159-2196. DOI:10.1080/10643389.2020.1777815

Merle, R., Hajek, P., Käsbohrer, A., Hegger-Gravenhorst, C., Mollenhauer, Y., Robanus, M., ...&Kreienbrock, L. (2012). Monitoring of antibiotic consumption in livestock: a German feasibility study. Preventive veterinary medicine, 104(1-2), 34-43. DOI: 10.1016/j.prevetmed.2011.10.013

van den Bogaard, A. E., &Stobberingh, E. E. (2000). Epidemiology of resistance to antibiotics: links between animals and humans. International journal of antimicrobial agents, 14(4), 327-335. DOI: 10.1016/S0924-8579(00)00145-X

Zalewska, M., Błażejewska, A., Czapko, A., &Popowska, M. (2021). Antibiotics and ABRgenes in animal manure–consequences of its application in agriculture. Frontiers in Microbiology, 12, 640. DOI: 10.3389/fmicb.2021.610656

Mesa Varona, O., Chaintarli, K., Muller-Pebody, B., Anjum, M. F., Eckmanns, T., Norström, M., ...&Tenhagen, B. A. (2020). Monitoring antimicrobial resistance and drug usage in the human and livestock sector and foodborne antimicrobial resistance in six European countries. Infection and drug resistance, 957-993.DOI: 10.2147/IDR.S237038

Grace, D. (2015). Review of evidence on antimicrobial resistance and animal agriculture in developing countries. DOI: 10.12774/eod_cr.june2015.graced

Vidovic, N., &Vidovic, S. (2020). Antimicrobial resistance and food animals: Influence of livestock environment on the emergence and dissemination of antimicrobial resistance. Antibiotics, 9(2), 52.DOI: 10.3390/antibiotics9020052

Patel, S. J., Wellington, M., Shah, R. M., & Ferreira, M. J. (2020). Antibiotic stewardship in food-producing animals: challenges, progress, and opportunities. Clinical therapeutics, 42(9), 1649-1658. DOI:10.1016/j.clinthera.2020.07.004

Thapa, S. P., Shrestha, S., & Anal, A. K. (2020). Addressing the ABRand improving the food safety in food supply chain (farm-to-fork) in Southeast Asia. Food Control, 108, 106809. DOI: 10.1016/j.foodcont.2019.106809

Jeżak, K., &Kozajda, A. (2022). Occurrence and spread of antibiotic-resistant bacteria on animal farms and in their vicinity in Poland and Ukraine. Environmental Science and Pollution Research, 29(7), 9533-9559. DOI: 10.1007/s11356-021-17773-z

He, Y., Yuan, Q., Mathieu, J., Stadler, L., Senehi, N., Sun, R., & Alvarez, P. J. (2020). ABRgenes from livestock waste: occurrence, dissemination, and treatment. NPJ Clean Water, 3(1), 4. DOI: 10.1038/s41545-020-0051-0

Ben, Y., Fu, C., Hu, M., Liu, L., Wong, M. H., &Zheng, C. (2019). Human health risk assessment of ABRassociated with antibiotic residues in the environment: A review. Environmental research, 169, 483-493. DOI:10.1016/j.envres.2018.11.040

Tian, M., He, X., Feng, Y., Wang, W., Chen, H., Gong, M., ...& van Eerde, A. (2021). Pollution by antibiotics and antimicrobial resistance in livestock and poultry manure in China, and countermeasures. Antibiotics, 10(5), 539. DOI:10.3390/antibiotics10050539

Mdegela, R. H., Mwakapeje, E. R., Rubegwa, B., Gebeyehu, D. T., Niyigena, S., Msambichaka, V., ...&Fasina, F. O. (2021). Antimicrobial use, residues, resistance and governance in the food and agriculture sectors, Tanzania. Antibiotics, 10(4), 454. DOI:10.3390/antibiotics10040454

Serwecińska, L. (2020). Antimicrobials and antibiotic-resistant bacteria: a risk to the environment and to public health. Water, 12(12), 3313. DOI:10.3390/w12123313

Da Silva, R. A., Arenas, N. E., Luiza, V. L., Bermudez, J. A. Z., & Clarke, S. E. (2023). Regulations on the use of antibiotics in livestock production in South America: a comparative literature analysis. Antibiotics, 12(8), 1303. DOI:10.3390/antibiotics12081303

Pokharel, S., Shrestha, P., &Adhikari, B. (2020). Antimicrobial use in food animals and human health: time to implement ‘One Health’approach. Antimicrobial Resistance & Infection Control, 9, 1-5. DOI:10.1186/s13756-020-00847-x

Vieco-Saiz, N., Belguesmia, Y., Raspoet, R., Auclair, E., Gancel, F., Kempf, I., &Drider, D. (2019). Benefits and inputs from lactic acid bacteria and their bacteriocins as alternatives to antibiotic growth promoters during food-animal production. Frontiers in microbiology, 10, 57. DOI:10.3389/fmicb.2019.00057

Plata, G., Baxter, N. T., Susanti, D., Volland-Munson, A., Gangaiah, D., Nagireddy, A., ...& Kumar Mahajan, A. (2022). Growth promotion and antibiotic induced metabolic shifts in the chicken gut microbiome. Communications Biology, 5(1), 293.DOI:10.1038/s42003-022-03239-6

Swaggerty, C. L., Bortoluzzi, C., Lee, A., Eyng, C., Pont, G. D., &Kogut, M. H. (2022). Potential replacements for antibiotic growth promoters in poultry: interactions at the gut level and their impact on host immunity. Recent Advances in Animal Nutrition and Metabolism, 145-159. DOI:10.1007/978-3-030-85686-1_8

Rahman, M. R. T., Fliss, I., &Biron, E. (2022). Insights in the development and uses of alternatives to antibiotic growth promoters in poultry and swine production. Antibiotics, 11(6), 766. DOI:10.3390/antibiotics11060766

Published
2023-12-31
How to Cite
Pravesh Belwal, Prasanna Mathad, Jayashree M kudari. (2023). Antibiotics in Livestock Production: A Comprehensive Examination of Usage, Resistance, and Regulatory Imperatives for Enhanced Oversight. Revista Electronica De Veterinaria, 24(3), 25-34. Retrieved from https://veterinaria.org/index.php/REDVET/article/view/392
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Articles