Synthesis And In Vitro Biological Evaluation Of Metal Complexes Of 2-Aminobenzothiazole
Abstract
Antibiotic resistance is a growing problem in today’s healthcare which increase the demand of heterocyclic compounds. Heterocyclic compound bears different biological activity, like anti-cancer, anti-inflammatory, anti-oxidant, antibacterial, etc. therefor its demand increase in development of new compounds to overcome microbial resistance. The coordination chemistry of 2-aminobenzothiazole, which possesses potential coordinating sites including one exocyclic (NH2) and two endocyclic (N and S), has received significant attention in recent decades. The interest has led to the discovery of various transition metal complexes exhibiting diverse structures. 2-amino benzothiazole and substituted aldehyde (2,4 dichlorbenzaldehyde ,4-benzyloxybenzaldehyde) used as a reactant in synthetic organic chemistry and also used for making Schiff base ligand for increase the potency of the final product. The reaction of the Schiff bases (SB1 and SB2) with the core metals like Cobalt chloride, manganese chloride, nickel chloride, and copper (II) has produced metal complexes (MC1-8) of Schiff bases. In our study, we employed the DPPH assay and the agar diffusion method to assess the anti-oxidant and antimicrobial characteristics of the synthesized ligands and their metal complexes
References
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