Synthesis And In Vitro Biological Evaluation Of Metal Complexes Containing 2-Aminothiazole
Keywords:
Aminothiazole, antibacterial, antifungal, antioxidant, Schiff’s base, metal complxes
Abstract
In the present study, Schiff bases and metal complexes containing 2-aminothiazole have been synthesized and characterized by physicochemical and spectral means. Broth dilution assay (96 well microtiter plate method) was used to evaluate antimicrobial activity of the synthesized compounds against Gram positive bacteria (B. subtilis), Gram negative bacteria (E. coli) and fungal species (A. niger and A. terreus) using cefadroxil (antibacterial) and fluconazole (antifungal) as standard drugs. Among the synthesized derivatives, Schiff base EVL1 showed good activity against A. niger, A. terreus, B. subtilis (MICan,at,bs = 3.12 µg/ml). Complex MV1 showed good antifungal activity against A. niger (MICan = 1.56 µg/ml) similarly complex MV1 showed significant activity against E. coli, B. subtilis and A. terreus (MICec,bs,at = 3.12 µ/ml) and MV5 against A. niger (MICan = 1.56 µ/ml). Antioxidant (DPPH assay) 1,1-Diphenyl-2-picrylhydrazyl assay activity of the synthesized derivatives was determined using weight loss method. Schiff base MV1 showed excellent antioxidant activity (IC50 = 46.56).
References
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4. Belin, P., & Zatorre, R. J. (2003). Adaptation to speaker's voice in right anterior temporal lobe. Neuroreport, 14(16), 2105-2109.Soliman MH, Mohamed GG. Cr (III), Mn (II), Fe (III), Co (II), Ni (II), Cu (II) and Zn (II) new complexes of 5-aminosalicylic acid: spectroscopic, thermal characterization and biological activity studies. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2013 Apr 15;107:8-15.
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6. Das D, Sikdar P, Bairagi M. Recent developments of 2-aminothiazoles in medicinal chemistry. European Journal of Medicinal Chemistry. 2016 Feb 15;109:89-98.
7. Neelakantan MA, Marriappan SS, Dharmaraja J, Jeyakumar T, Muthukumaran K. Spectral, XRD, SEM and biological activities of transition metal complexes of polydentate ligands containing thiazole moiety. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2008 Nov 15;71(2):628-35.
8. Shirodkar SG, Mane PS, Chondhekar TK. Synthesis and fungitoxic studies of Mn (II), Co (II), Ni (II) and Cu (II) with some heterocyclic Schiff base ligands.
9. Laine 2012 Laine L, Kivitz AJ, Bello AE, Grahn AY, Schiff MH, Taha AS. Double-blind randomized trials of single-tablet ibuprofen/high-dose famotidine vs. ibuprofen alone for reduction of gastric and duodenal ulcers. The American journal of gastroenterology. 2012 Mar;107(3):379
10. Borelli 2008 Borelli C, Schaller M, Niewerth M, Nocker K, Baasner B, Berg D, Tiemann R, Tietjen K, Fugmann B, Lang-Fugmann S, Korting HC. Modes of action of the new arylguanidine abafungin beyond interference with ergosterol biosynthesis and in vitro activity against medically important fungi. Chemotherapy. 2008;54(4):245-59.
11. Guay 2002 Guay DR. Cefdinir: an advanced-generation, broad-spectrum oral cephalosporin. Clinical therapeutics. 2002 Apr 1;24(4):473-89.
12. Lugar 1996 Luger P, Daneck K, Engel W, Trummlitz G, Wagner K. Structure and physicochemical properties of meloxicam, a new NSAID. European Journal of Pharmaceutical Sciences. 1996 May 1;4(3):175-87.
13. Chen BC, Zhao R, Wang B, Droghini R, Lajeunesse J, Sirard P, Endo M, Balasubramanian B, Barrish JC. A new and efficient preparation of 2-aminothiazole-5-carbamides: applications to the synthesis of the anti-cancer drug dasatinib. Arkivoc. 2010 Jan 1;6:32-8.
14. Ayati A, Emami S, Moghimi S, Foroumadi A. Thiazole in the targeted anticancer drug discovery. Future Medicinal Chemistry. 2019 Aug;11(16):1929-52.
15. Kalemba, D. A. A. K., & Kunicka, A. (2003). Antibacterial and antifungal properties of essential oils. Current medicinal chemistry, 10(10), 813-829.
16. Andrews, J. M. (2001). Determination of minimum inhibitory concentrations. Journal of antimicrobial Chemotherapy, 48(suppl_1), 5-16.
17. Mukherjee, P., Ahmad, A., Mandal, D., Senapati, S., Sainkar, S. R., Khan, M. I., ... & Kumar, R. (2001). Bioreduction of AuCl4-ions by the fungus, Verticillium sp. and surface trapping of the gold nanoparticles formed. Angewandte Chemie-International Edition, 40(19), 3585-3588.
Published
2024-06-26
How to Cite
Aditay Kumar, Mohd Hussain, Mamta khatak, Mohit Verma, Mohd Isfaq, Sudhir kaushik, & Mahesh Kumar. (2024). Synthesis And In Vitro Biological Evaluation Of Metal Complexes Containing 2-Aminothiazole. Revista Electronica De Veterinaria, 25(1S), 93-109. Retrieved from https://veterinaria.org/index.php/REDVET/article/view/566
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Articles
