Synergistic Effect of Combined Antibiotic and Asparagus racemosus Bark Extract as a Potent Antimicrobial Activity

  • Namrata Patel
  • Niharika Jegoda
  • Kinjal Patel
  • Piyush J. Vyas
Keywords: Asparagus racemosus, HPTLC, Antibiotics, Antimicrobial Activity

Abstract

Antimicrobial drugs derived from plants alone cannot protect against diseases due to some limitations against bacterial growth in the environment. Research has consistently shown thatantibiotics derived from plants are synergistic; this means that although they contain fewer antibiotics when taken alone, they make the drug more effective when combined with medication. Antibiotics and herbal extracts work synergistically to prevent drug resistance, opening new avenues for treating infectious diseases. The synergistic effect of plant extracts and antibiotics was analyzed using the agar positive diffusion method. According to the research results, the activity level was higher when Asparagus racemosa plant extract was combined with antibacterial drugs. The results of this study suggest that combining plant extracts with antibiotics may be beneficial for newly developed antibiotics. According to HPTLC data, the combination of antibiotics with antibiotics does not lead to new compounds.

 

 

Author Biographies

Namrata Patel

Department of Chemistry, Sheth M. N. Science College, Patan-384265, Gujarat, India.

Niharika Jegoda

Department of Chemistry, Gokul Science College, Sidhpur-384151, Gujarat, India.

 

Kinjal Patel

Department of Chemistry, Sheth M. N. Science College, Patan-384265, Gujarat, India.

Piyush J. Vyas

Department of Chemistry, Sheth M. N. Science College, Patan-384265, Gujarat, India.

References

Goyal, R. K., Singh, J., & Lal, H. (2003). Asparagus racemosus-an update. Indian journal of medical sciences, 57(9), 408-414.

Alok, S., Jain, S. K., Verma, A., Kumar, M., Mahor, A., & Sabharwal, M. (2013). Plant profile, phytochemistry and pharmacology of Asparagus racemosus (Shatavari): A review. Asian Pacific journal of tropical disease, 3(3), 242-251.

Hasan, N., Ahmad, N., Zohrameena, S., Khalid, M., & Akhtar, J. (2016). Asparagus racemosus: for medicinal uses & pharmacological actions. International Journal of Advanced Research, 4(3), 259-267.

Potduang, B., Meeploy, M., Giwanon, R., Benmart, Y., Kaewduang, M., & Supatanakul, W. (2008). Biological activities of Asparagus racemosus. African Journal of Traditional, Complementary and Alternative Medicines, 5(3), 230-237.

Sachan, A. K., Das, D. R., Dohare, S. L., & Shuaib, M. (2012). Asparagus racemosus (Shatavari): an overview. Int J Pharm Chem Sci, 1(3), 588-592.

Mandal, S. C., Nandy, A., Pal, M., & Saha, B. P. (2000). Evaluation of antibacterial activity of Asparagus racemosus Willd. root. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 14(2), 118-119.

Battu, G. R., & Kumar, B. M. (2010). Phytochemical and antimicrobial activity of leaf extract of Asparagus racemosus Willd. Pharmacognosy Journal, 2(12), 456-463.

Sairam, K., Priyambada, S., Aryya, N. C., & Goel, R. K. (2003). Gastroduodenal ulcer protective activity of Asparagus racemosus: an experimental, biochemical and histological study. Journal of ethnopharmacology, 86(1), 1-10.

Hayes, P. Y., Jahidin, A. H., Lehmann, R., Penman, K., Kitching, W., & De Voss, J. J. (2008). Steroidal saponins from the roots of Asparagus racemosus. Phytochemistry, 69(3), 796-804.

Mishra, J. N., & Verma, N. K. (2017). Asparagus racemosus: Chemical constituents and pharmacological activities—A review. Eur. J. Biomed. Pharm. Sci, 4, 207-213.

Singh, G. K., Garabadu, D., Muruganandam, A. V., Joshi, V. K., & Krishnamurthy, S. (2009). Antidepressant activity of Asparagus racemosus in rodent models. Pharmacology Biochemistry and Behavior, 91(3), 283-290.

Kumar, S., Mehla, R. K., & Dang, A. K. (2008). Use of shatavari (Asparagus racemosus) as a galactopoietic and therapeutic herb–a review. Agricultural Reviews, 29(2), 132-138.

Venkatesan, N., Thiyagarajan, V., Narayanan, S., Arul, A., Raja, S., Kumar, S. V., ... & Perianayagam, J. B. (2005). Anti-diarrhoeal potential of Asparagus racemosus wild root extracts in laboratory animals. J Pharm Pharm Sci, 8(1), 39-46.

Choudhary, D., & Sharma, D. (2014). A phytopharmacological review on Asparagus racemosus. Int J Sci Res, 3(7), 742-746.

Sharma, M., Sharma, A., & Kumar, A. (2012). Vital medicine Asparagus racemosus willd. Current Trends in Biotechnology and Pharmacy, 6(2), 210-221.

Velavan, S., Nagulendran, K. R., Mahesh, R., & Begum, V. H. (2007). Phcog Rev.: plant review the chemistry, pharmacological and therapeutic applications of Asparagus racemosus-a review. Pharmacognosy Reviews, 1(2), 350-360.

Sharma, A., Chadha, N. K., Das, S. K., Sen, A., Roy, S., Chanu, T. I., ... & Prakash, C. (2018). Asparagus racemosus aqueous root extract induced effects on cellular immune reaction of Labeo rohita (Hamilton). Indian Journal of Animal Sciences, 88(2), 251-258.

Kumar, A. S. H. W. A. N. I., & Vijay, N. E. E. T. U. (2009). In vitro plantlet regeneration in Asparagus racemosus through shoot bud differentiation on nodal segments.

Vijay, N., Kumar, A., & Bhoite, A. (2009). Influence of nitrogen, phosphorus and potassium fertilizer on biochemical contents of Asparagus racemosus (Willd.) root tubers.

Sharma, M., Sharma, A., & Kumar, A. (2011). Ethnopharmacological importance of Asparagus racemosus: A review. J Pharm Biomed Sci, 6(06).

Published
2024-07-25
How to Cite
Namrata Patel, Niharika Jegoda, Kinjal Patel, & Piyush J. Vyas. (2024). Synergistic Effect of Combined Antibiotic and Asparagus racemosus Bark Extract as a Potent Antimicrobial Activity. Revista Electronica De Veterinaria, 24(2), 541-546. https://doi.org/10.69980/redvet.v24i2.654
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Articles