“Synthesis And Characterization Of New Derivatives Of Pyrazole And Screened For Their Antitubercular Potential”
Abstract
Antimicrobials are substances that kill or prevent harmful microorganisms from multiplying or growing. There are three types of microbes: bacteria, viruses, and fungus. Mycobacterium tuberculosis, a common cause of tuberculosis, is one of the most harmful pathogenic microorganisms. Tuberculosis is transmitted through aerosol and inhalation, and its pathogenesis is divided into two phases. Antibacterial medicines, such as penicillin, cephalosporins, aminoglycosides, and quinolones, are widely available and help manage most bacterial illnesses. Pyrazoles, a white liquid with a five-membered two-nitrogen heterocyclic molecule, have various biological activities, including antibacterial, antitubercular, antiviral, anticancer, antimicrobial, and antioxidant properties. Studies have shown that pyrazole derivatives with various substituents on two carbon atoms next to the nitrogen atoms can be highly active and respond quickly to produce different moieties. In medicinal chemistry, thiazole, or 1,3-thiazole, is a heterocyclic molecule with a vast family of derivatives and is a transparent to light yellow liquid with a pyridine-like odor. The intriguing pharmacological characteristics of thiazole derivatives in response to various structural alterations are worth investigating to create high-effective drugs with minimal side effects.
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