Microplastics And Nanoplastics: Environmental Sources, Human Exposure Pathways, And Potential Health Impacts

  • Wilson Joel Rodrigues
  • Meena Kumari H R
  • Satish Kumar J

Abstract

Plastics have a profound impact on daily life, including packaging, medicine, and household items. Their disposal after single use and subsequent breakdown into micro- and nano-plastics raise significant concerns about their effects on ecosystems and human health. Microplastics and nanoplastics have emerged as ubiquitous contaminants in natural and human-made environments, including oceans, freshwater systems, and the atmosphere. These particles have been implicated in sources of human exposure including contaminated seafood, drinking water, and various food items, exacerbated by migration from packaging materials. This systematic review synthesizes current literature on the sources, pathways, and health impacts of these particles, focusing on human exposure and associated risks. Microplastics and nanoplastics can enter the human body primarily through ingestion, inhalation, and dermal contact, posing potential health risks such as oxidative damage, inflammation, and disruption of physiological processes in the gastrointestinal, central nervous system, nephrons and respiratory systems leading towards gastrointestinal disturbances, neurotoxicity, nephropathy, and respiratory diseases. This paper aims to inspire further studies to understand the full extent of microplastic and nanoplastic contamination, their interaction with biological pathways and the implementation of effective regulatory measures to mitigate human health risks associated with these particles.  

Author Biographies

Wilson Joel Rodrigues

Division of Biochemistry, School of Life Sciences, JSS Academy of Higher Education and Research, Shivarrathreeshwara Nagar, Mysuru -570015

Meena Kumari H R

Dept of Environmental Science, KSOU, Mysore

Satish Kumar J

Department of Environmental Sciences, School of Life Sciences, JSS Academy of Higher Education and Research, Shivarrathreeshwara Nagar, Mysuru – 570015

References

1. Ali, N., Khan, M.H., Ali, M., Ahmad, S., Khan, A., Nabi, G., Ali, F., Bououdina, M. and Kyzas, G.Z., 2023. Insight into microplastics in the aquatic ecosystem: Properties, sources, threats and mitigation strategies. Science of the Total Environment, p.169489.
2. Altunısık, A., 2023. Microplastic pollution and human risk assessment in Turkish bottled natural and mineral waters. Environmental Science and Pollution Research, 30(14), pp.39815-39825.
3. Amobonye, A., Bhagwat, P., Raveendran, S., Singh, S. and Pillai, S., 2021. Environmental impacts of microplastics and nanoplastics: a current overview. Frontiers in Microbiology, 12, p.768297.
4. Anuar, N.A.S., Pang, L., Selvam, S.B., Gibbins, C. and Ting, K., 2021. Polyethylene microplastics adversely affect airway patency. Life Sci. Med. Biomed, 6(1), p.93.
5. Barboza, Luís Gabriel Antao, Luís Russo Vieira, Vasco Branco, Neusa Figueiredo, Felix Carvalho, Cristina Carvalho, and Lúcia Guilhermino. "Microplastics cause neurotoxicity, oxidative damage and energy-related changes and interact with the bioaccumulation of mercury in the European seabass, Dicentrarchus labrax (Linnaeus, 1758)." Aquatic toxicology 195 (2018): 49-57.
6. Campanale, C., Massarelli, C., Savino, I., Locaputo, V. and Uricchio, V.F., 2020. A detailed review study on the potential effects of microplastics and additives of concern on human health. International Journal of Environmental Research and Public Health, 17(4), p.1212.
7. Caputi, S., Diomede, F., Lanuti, P., Marconi, G.D., Di Carlo, P., Sinjari, B. and Trubiani, O., 2022. Microplastics affect the inflammation pathway in human gingival fibroblasts: A study in the Adriatic Sea. International Journal of Environmental Research and Public Health, 19(13), p.7782.
8. Djouina, M., Vignal, C., Dehaut, A., Caboche, S., Hirt, N., Waxin, C., Himber, C., Beury, D., Hot, D., Dubuquoy, L. and Launay, D., 2022. Oral exposure to polyethene microplastics alters gut morphology, immune response, and microbiota composition in mice. Environmental Research, 212, p.113230.
9. Dong, C.D., Chen, C.W., Chen, Y.C., Chen, H.H., Lee, J.S. and Lin, C.H., 2020. Polystyrene microplastic particles: In vitro pulmonary toxicity assessment. Journal of hazardous materials, 385, p.121575.
10. Du, F., Cai, H., Zhang, Q., Chen, Q. and Shi, H., 2020. Microplastics in take-out food containers. Journal of Hazardous Materials, 399, p.122969.
11. Enyoh, C.E., Shafea, L., Verla, A.W., Verla, E.N., Qingyue, W., Chowdhury, T. and Paredes, M., 2020. Microplastics exposure routes and toxicity studies to ecosystems: an overview. Environmental analysis, health and toxicology, 35(1).
12. Fackelmann, G. and Sommer, S., 2019. Microplastics and the gut microbiome: how chronically exposed species may suffer from gut dysbiosis. Marine Pollution Bulletin, 143, pp.193-203.
13. Fadare, O.O., Wan, B., Guo, L.H. and Zhao, L., 2020. Microplastics from consumer plastic food containers: are we consuming it? Chemosphere, 253, p.126787.
14. Fournier, E., Etienne-Mesmin, L., Grootaert, C., Jelsbak, L., Syberg, K., Blanquet-Diot, S. and Mercier-Bonin, M., 2021. Microplastics in the human digestive environment: a focus on the potential and challenges facing in vitro gut model development. Journal of hazardous materials, 415, p.125632.
15. Garside, M., 2019. Global plastic production statistics. Retrieved from Statista.
16. Giri, S., Lamichhane, G., Khadka, D. and Devkota, H.P., 2024. Microplastics contamination in food products: Occurrence, analytical techniques and potential impacts on human health. Current Research in Biotechnology, p.100190.
17. Godoy, V., Martinez-Ferez, A., Martín-Lara, M.Á., Vellido-Pérez, J.A., Calero, M. and Blázquez, G., 2020. Microplastics as vectors of chromium and lead during dynamic simulation of the human gastrointestinal tract. Sustainability, 12(11), p.4792.
18. Han, S.W., Choi, J. and Ryu, K.Y., 2024. Recent progress and future directions of the research on nanoplastic-induced neurotoxicity. Neural regeneration research, 19(2), pp.331-335.
19. Harms, I.K., Diekötter, T., Troegel, S. and Lenz, M., 2021. Amount, distribution and composition of large microplastics in typical agricultural soils in Northern Germany. Science of the Total Environment, 758, p.143615.
20. Hernandez, L.M., Xu, E.G., Larsson, H.C., Tahara, R., Maisuria, V.B. and Tufenkji, N., 2019. Plastic teabags release billions of microparticles and nanoparticles into tea. Environmental science & technology, 53(21), pp.12300-12310.
21. Hu, M. and Palić, D., 2020. Micro-and nano-plastics activation of oxidative and inflammatory adverse outcome pathways. Redox biology, 37, p.101620.
22. Huang, Z., Weng, Y., Shen, Q., Zhao, Y. and Jin, Y., 2021. Microplastic: a potential threat to human and animal health by interfering with the intestinal barrier function and changing the intestinal microenvironment. Science of the Total Environment, 785, p.147365.
23. Jadhav, E.B., Sankhla, M.S., Bhat, R.A. and Bhagat, D.S., 2021. Microplastics from food packaging: An overview of human consumption, health threats, and alternative solutions. Environmental Nanotechnology, Monitoring & Management, 16, p.100608.
24. Jeon, M.S., Kim, J.W., Han, Y.B., Jeong, M.H., Kim, H.R., Sik Kim, H., Park, Y.J. and Chung, K.H., 2023. Polystyrene microplastic particles induce autophagic cell death in BEAS‐2B human bronchial epithelial cells. Environmental Toxicology, 38(2), pp.359-367.
25. Kadac-Czapska, K., Knez, E. and Grembecka, M., 2024. Food and human safety: The impact of microplastics. Critical Reviews in Food Science and Nutrition, 64(11), pp.3502-3521.
26. Kedzierski, M., Lechat, B., Sire, O., Le Maguer, G., Le Tilly, V. and Bruzaud, S., 2020. Microplastic contamination of packaged meat: Occurrence and associated risks. Food Packaging and Shelf Life, 24, p.100489.
27. Kwon, J.H., Kim, J.W., Pham, T.D., Tarafdar, A., Hong, S., Chun, S.H., Lee, S.H., Kang, D.Y., Kim, J.Y., Kim, S.B. and Jung, J., 2020. Microplastics in food: a review on analytical methods and challenges. International journal of environmental research and public health, 17(18), p.6710.
28. Laskar, N. and Kumar, U., 2019. Plastics and microplastics: A threat to the environment. Environmental technology & innovation, 14, p.100352.
29. Lei, L., Liu, M., Song, Y., Lu, S., Hu, J., Cao, C., Xie, B., Shi, H. and He, D., 2018. Polystyrene (nano) microplastics cause size-dependent neurotoxicity, oxidative damage and other adverse effects in Caenorhabditis elegans. Environmental Science: Nano, 5(8), pp.2009-2020.
30. Li, Y., Peng, L., Fu, J., Dai, X. and Wang, G., 2022. A microscopic survey on microplastics in beverages: the case of beer, mineral water and tea. Analyst, 147(6), pp.1099-1105.
31. Lu, K., Lai, K.P., Stoeger, T., Ji, S., Lin, Z., Lin, X., Chan, T.F., Fang, J.K.H., Lo, M., Gao, L. and Qiu, C., 2021. Detrimental effects of microplastic exposure on normal and asthmatic pulmonary physiology. Journal of hazardous materials, 416, p.126069.
32. Lu, W., Li, X., Wang, S., Tu, C., Qiu, L., Zhang, H., Zhong, C., Li, S., Liu, Y., Liu, J. and Zhou, Y., 2023. New evidence of microplastics in the lower respiratory tract: inhalation through smoking. Environmental Science & Technology, 57(23), pp.8496-8505.
33. Nalbone, L., Cincotta, F., Giarratana, F., Ziino, G. and Panebianco, A., 2021. Microplastics in fresh and processed mussels sampled from fish shops and large retail chains in Italy. Food Control, 125, p.108003.
34. Paul, M.B., Stock, V., Cara-Carmona, J., Lisicki, E., Shopova, S., Fessard, V., Braeuning, A., Sieg, H. and Böhmert, L., 2020. Micro-and nanoplastics–current state of knowledge with the focus on oral uptake and toxicity. Nanoscale Advances, 2(10), pp.4350-4367.
35. Pironti, C., Ricciardi, M., Motta, O., Miele, Y., Proto, A. and Montano, L., 2021. Microplastics in the environment: intake through the food web, human exposure and toxicological effects. Toxics, 9(9), p.224.
36. Priya, A.K., Jalil, A.A., Dutta, K., Rajendran, S., Vasseghian, Y., Qin, J. and Soto-Moscoso, M., 2022. Microplastics in the environment: recent developments in characteristic, occurrence, identification and ecological risk. Chemosphere, 298, p.134161.
37. Prokic, M.D., Radovanović, T.B., Gavrić, J.P. and Faggio, C., 2019. Ecotoxicological effects of microplastics: Examination of biomarkers, current state and future perspectives. TrAC Trends in analytical chemistry, 111, pp.37-46.
38. Prust, M., Meijer, J. and Westerink, R.H., 2020. The plastic brain: neurotoxicity of micro-and nanoplastics. Particle and fibre toxicology, 17, pp.1-16.
39. Ramsperger, A.F., Bergamaschi, E., Panizzolo, M., Fenoglio, I., Barbero, F., Peters, R., Undas, A., Purker, S., Giese, B., Lalyer, C.R. and Tamargo, A., 2023. Nano-and microplastics: a comprehensive review on their exposure routes, translocation, and fate in humans. NanoImpact, 29, p.100441.
40. Rodrigues, A.C.B., de Jesus, G.P., Waked, D., Gomes, G.L., Silva, T.M., Yariwake, V.Y., da Silva, M.P., Magaldi, A.J. and Veras, M.M., 2022. Scientific evidence about the risks of micro and nanoplastics (MNPLs) to human health and their exposure routes through the environment. Toxics, 10(6), p.308.
41. Rojoni, S.A., Ahmed, M.T., Rahman, M., Hossain, M.M.M., Ali, M.S. and Haq, M., 2024. Advances of microplastic ingestion on the morphological and behavioural conditions of model zebrafish: A review. Aquatic Toxicology, p.106977.
42. Rose, P.K., Yadav, S., Kataria, N. and Khoo, K.S., 2023. Microplastics and nanoplastics in the terrestrial food chain: Uptake, translocation, trophic transfer, ecotoxicology, and human health risk. TrAC Trends in Analytical Chemistry, p.117249.
43. Savuca, A., Nicoara, M.N., Ciobica, A., Gorgan, D.L., Ureche, D. and Balmus, I.M., 2023. Current Aspects on the Plastic Nano-and Microparticles Toxicity in Zebrafish—Focus on the Correlation between Oxidative Stress Responses and Neurodevelopment. Animals, 13(11), p.1810.
44. Setala, O., Lehtiniemi, M., Coppock, R. and Cole, M., 2018. Microplastics in marine food webs. In Microplastic contamination in aquatic environments (pp. 339-363). Elsevier.
45. Shi, Q., Tang, J., Liu, R. and Wang, L., 2022. Toxicity in vitro reveals potential impacts of microplastics and nanoplastics on human health: A review. Critical Reviews in Environmental Science and Technology, 52(21), pp.3863-3895.
46. Shruti, V.C., Pérez-Guevara, F., Elizalde-Martínez, I. and Kutralam-Muniasamy, G., 2020. The first study of its kind on the microplastic contamination of soft drinks, cold tea and energy drinks-Future research and environmental considerations. Science of the total environment, 726, p.138580.
47. Siegel, L., 2018. Turning The Tide On Plastic. London: Trapeze.
48. Silva, M.G., Oliveira, M.M. and Peixoto, F., 2023. Assessing micro-and nanoplastics toxicity using rodent models: investigating potential mitochondrial implications. Toxicology, p.153656.
49. Stapleton, M.J. and Hai, F.I., 2023. Microplastics as an emerging contaminant of concern to our environment: a brief overview of the sources and implications. Bioengineered, 14(1), p.2244754.
50. Sun, A. and Wang, W.X., 2023. Human exposure to microplastics and its associated health risks. Environment & Health, 1(3), pp.139-149.
51. Szymanska, M. and Obolewski, K., 2020. Microplastics as contaminants in freshwater environments: A multidisciplinary review. Ecohydrology & Hydrobiology, 20(3), pp.333-345.
52. Talukdar, A., Kundu, P., Bhattacharya, S. and Dutta, N., 2024. Microplastic contamination in wastewater: Sources, distribution, detection and remediation through physical and chemical-biological methods. Science of The Total Environment, p.170254.
53. Van Dijk, F., Song, S., van Eck, G.W.A., Wu, X., Bos, I.S.T., Boom, D.H.A., Kooter, I.M., Spierings, D.C.J., Wardenaar, R., Cole, M. and Salvati, A., 2021. Inhalable textile microplastic fibres impair airway epithelial growth. Biorxiv, pp.2021-01.
54. Wang, W., Guan, J., Feng, Y., Nie, L., Xu, Y., Xu, H. and Fu, F., 2023. Polystyrene microplastics induced nephrotoxicity associated with oxidative stress, inflammation, and endoplasmic reticulum stress in juvenile rats. Frontiers in Nutrition, 9, p.1059660.
55. Wen, J., Sun, H., Yang, B., Song, E., Song, Y. and Jiang, G., 2024. Environmentally Relevant Concentrations of Microplastic Exposure Cause Cholestasis and Bile Acid Metabolism Dysregulation through a Gut-Liver Loop in Mice. Environmental Science & Technology, 58(4), pp.1832-1841.
56. Windheim, J., Colombo, L., Battajni, N.C., Russo, L., Cagnotto, A., Diomede, L., Bigini, P., Vismara, E., Fiumara, F., Gabbrielli, S. and Gautieri, A., 2022. Micro-and nanoplastics’ effects on protein folding and amyloidosis. International journal of molecular sciences, 23(18), p.10329.
57. Winiarska, E., Chaszczewska-Markowska, M., Ghete, D., Jutel, M. and Zemelka-Wiacek, M., 2024. Nanoplastics Penetrate Human Bronchial Smooth Muscle and Small Airway Epithelial Cells and Affect Mitochondrial Metabolism. International Journal of Molecular Sciences, 25(9), p.4724.
58. Wright, S.L., Ulke, J., Font, A., Chan, K.L.A. and Kelly, F.J., 2020. Atmospheric microplastic deposition in an urban environment and an evaluation of transport. Environment International, 136, p.105411.
59. Xu, M., Halimu, G., Zhang, Q., Song, Y., Fu, X., Li, Y., Li, Y. and Zhang, H., 2019. Internalization and toxicity: A preliminary study of effects of nanoplastic particles on human lung epithelial cell. Science of the Total Environment, 694, p.133794.
60. Xu, X., Goros, R.A., Dong, Z., Meng, X., Li, G., Chen, W., Liu, S., Ma, J. and Zuo, Y.Y., 2023. Microplastics and nanoplastics impair the biophysical function of pulmonary surfactant by forming heteroaggregates at the alveolar–capillary interface. Environmental Science & Technology, 57(50), pp.21050-21060.
61. Yee, M.S.L., Hii, L.W., Looi, C.K., Lim, W.M., Wong, S.F., Kok, Y.Y., Tan, B.K., Wong, C.Y. and Leong, C.O., 2021. Impact of microplastics and nanoplastics on human health. Nanomaterials, 11(2), p.496.
62. Zhang, J., Chen, Z., Shan, D., Wu, Y., Zhao, Y., Li, C., Shu, Y., Linghu, X. and Wang, B., 2024. Adverse effects of exposure to fine particles and ultrafine particles in the environment on different organs of organisms. Journal of Environmental Sciences, 135, pp.449-473.
63. Ziani, K., Ioniță-Mîndrican, C.B., Mititelu, M., Neacșu, S.M., Negrei, C., Moroșan, E., Drăgănescu, D. and Preda, O.T., 2023. Microplastics: a real global threat for environment and food safety: a state of the art review. Nutrients, 15(3), p.617.
64. Zou, H., Chen, Y., Qu, H., Sun, J., Wang, T., Ma, Y., Yuan, Y., Bian, J. and Liu, Z., 2022. Microplastics exacerbate cadmium-induced kidney injury by enhancing oxidative stress, autophagy, apoptosis, and fibrosis. International Journal of Molecular Sciences, 23(22), p.14411.
Published
2024-08-25
How to Cite
Wilson Joel Rodrigues, Meena Kumari H R, & Satish Kumar J. (2024). Microplastics And Nanoplastics: Environmental Sources, Human Exposure Pathways, And Potential Health Impacts. Revista Electronica De Veterinaria, 25(1S), 537-543. https://doi.org/10.69980/redvet.v25i1S.750