Indian Propolis: Chemical Composition, Antioxidant and Antimicrobial Properties
Keywords:
antimicrobial activity, chemical constituent, antioxidant activity
Abstract
Propolis, a resinous substance collected by honeybees from various plant sources, has been utilized for centuries in traditional medicine due to its diverse biological activities. This research focuses on exploring the chemical composition, antioxidant potential and antimicrobial properties of Indian propolis.
The chemical constituents of Indian propolis were elucidated, revealing a complex mixture of phenolic compounds, flavonoids, terpenoids, and other bioactive substances. These constituents contribute significantly to the therapeutic properties exhibited by propolis.
Moreover, the antioxidant activity of Indian propolis revealed its capability to scavenge free radicals and protect against oxidative stress-induced damage. The findings underscore the potential application of Indian propolis as a natural antioxidant supplement for mitigating oxidative stress-related diseases.
Furthermore, the antimicrobial properties of Indian propolis were investigated against different standard pathogens. Results revealed its effectiveness in inhibiting bacterial growth, suggesting its potential as an alternative or adjunctive therapy for bacterial and fungal infections.
In conclusion, Indian propolis exhibits promising chemical composition, antioxidant potential and antimicrobial activity, highlighting its therapeutic significance and potential applications in pharmaceuticals, nutraceuticals, and cosmeceuticals. Further research is warranted to elucidate its mechanisms of action and explore its clinical efficacy in various health conditions.
References
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27. Martinotti, S., & Ranzato, E. (2015). Propolis: a new frontier for wound healing?. Burns & trauma, 3, 1-7.
28. Galeotti, F., Maccari, F., Fachini, A., & Volpi, N. (2018). Chemical composition and antioxidant activity of propolis prepared in different forms and in different solvents useful for finished products. Foods, 7(3), 41.
29. Paviani, L. C., Fiorito, G., Sacoda, P., & Cabral, F. A. (2013, April). Different solvents for extraction of Brazilian green propolis: Composition and extraction yield of phenolic compounds. In III Iberoamerican Conference on Supercritical Fluid (pp. 1-5).
30. Kubiliene, L., Laugaliene, V., Pavilonis, A., Maruska, A., Majiene, D., Barcauskaite, K., ... & Savickas, A. (2015). Alternative preparation of propolis extracts: comparison of their composition and biological activities. BMC complementary and alternative medicine, 15, 1-7.
31. Sun, C., Wu, Z., Wang, Z., & Zhang, H. (2015). Effect of ethanol/water solvents on phenolic profiles and antioxidant properties of Beijing propolis extracts. Evidence‐Based Complementary and Alternative Medicine, 2015(1), 595393.
32. Kara, Y., Can, Z., & Kolaylı, S. (2022). What should be the ideal solvent percentage and solvent-propolis ratio in the preparation of ethanolic propolis extract?. Food Analytical Methods, 15(6), 1707-1719.
33. Mulyati, A. H., Sulaeman, A., Marliyati, S. A., Rafi, M., & Fikri, A. M. (2020, June). Phytochemical analysis and antioxidant activities of ethanol extract of stingless bee propolis from Indonesia. In AIP Conference Proceedings (Vol. 2243, No. 1). AIP Publishing.
34. Kumar, N., Ahmad, M. K. K., Dang, R., & Husain, A. (2008). Antioxidant and antimicrobial activity of propolis from Tamil Nadu zone. Journal of Medicinal Plants Research, 2(12), 361-364.
35. Sowmya, S., Gujjari, A. K., Mruthunjaya, K., Padmanabhan, T. V., Anupama, C., Sushma, R., & Gaekwad, S. S. (2019). Antioxidant and antimicrobial activity of propolis.
36. Park, Y. K., & Ikegaki, M. (1998). Preparation of water and ethanolic extracts of propolis and evaluation of the preparations. Bioscience, biotechnology, and biochemistry, 62(11), 2230-2232.
37. Sokolonski, A. R., Fonseca, M. S., Machado, B. A. S., Deegan, K. R., Araújo, R. P. C., Umsza-Guez, M. A., & Portela, R. W. (2021). Activity of antifungal drugs and Brazilian red and green propolis extracted with different methodologies against oral isolates of Candida spp. BMC complementary medicine and therapies, 21, 1-14.
38. Dönmez, M., Karadeniz, Ş., Yoldas, T., Aydın, G., Karagül, P., Aksu, O., & Rasgele, P. G. (2020). Comparison of chemical contents of extracts in different solvents of propolis samples produced in Duzce province. International Journal of Traditional and Complementary Medicine Research, 1(3), 137-146.
39. https://www.iitb.ac.in
2. Zafar, Muhammad Sohail, and Khalid H. Al-Samadani. "Potential use of natural silk for bio-dental applications." Journal of Taibah University Medical Sciences 9.3 (2014): 171-177.
3. Husain, Shehriar, et al. "Chitosan biomaterials for current and potential dental applications." Materials 10.6 (2017): 602.
4. Qasim, Saad B., et al. "Potential of electrospun chitosan fibers as a surface layer in functionally graded GTR membrane for periodontal regeneration." dental materials 33.1 (2017): 71-83.
5. Khurshid, Zohaib, et al. "Suppl-1, M3: Green Tea (Camellia Sinensis): Chemistry and Oral Health." The open dentistry journal 10 (2016): 166.
6. Niazi, Fayez, et al. "Role of Salvadora persica chewing stick (miswak): A natural toothbrush for holistic oral health." European journal of dentistry 10.2 (2016): 301.
7. Sforcin, José Maurício, and Vassya Bankova. "Propolis: is there a potential for the development of new drugs?." Journal of ethnopharmacology 133.2 (2011): 253-260.
8. Freires, Irlan Almeida, Severino Matias de Alencar, and Pedro Luiz Rosalen. "A pharmacological perspective on the use of Brazilian Red Propolis and its isolated compounds against human diseases." European journal of medicinal chemistry110 (2016): 267-279.
9. Burdock, G. A. "Review of the biological properties and toxicity of bee propolis (propolis)." Food and Chemical toxicology 36.4 (1998): 347-363.
10. Marcucci, Maria Cristina. "Propolis: chemical composition, biological properties and therapeutic activity." Apidologie 26.2 (1995): 83-99.
11. Huang, Shuai, et al. "Recent advances in the chemical composition of propolis." Molecules 19.12 (2014): 19610-19632.
12. Kalogeropoulos, Nick, et al. "Chemical composition, antioxidant activity and antimicrobial properties of propolis extracts from Greece and Cyprus." Food chemistry 116.2 (2009): 452-461.
13. Stepanović, Srdjan, et al. "In vitro antimicrobial activity of propolis and synergism between propolis and antimicrobial drugs." Microbiological Research 158.4 (2003): 353-357.
14. McLennan, Susan V., et al. "The anti‐inflammatory agent Propolis improves wound healing in a rodent model of experimental diabetes." Wound Repair and Regeneration 16.5 (2008): 706-713.
15. Ramos, A. F. N., and JL de Miranda. "Propolis: a review of its anti-inflammatory and healing actions." Journal of Venomous Animals and Toxins Including Tropical Diseases 13.4 (2007): 697-710.
16. Curti, V., Zaccaria, V., Tsetegho Sokeng, A. J., Dacrema, M., Masiello, I., Mascaro, A., ... & Daglia, M. (2019). Bioavailability and in vivo antioxidant activity of a standardized polyphenol mixture extracted from brown propolis. International journal of molecular sciences, 20(5), 1250.
17. Russo, A., Longo, R., & Vanella, A. (2002). Antioxidant activity of propolis: role of caffeic acid phenethyl ester and galangin. Fitoterapia, 73, S21-S29..
18. Sawaya, Alexandra CHF, et al. "Electrospray ionization mass spectrometry fingerprinting of propolis." Analyst 129.8 (2004): 739-744.
19. Miguel, Maria Graça, et al. "Phenols, flavonoids and antioxidant activity of aqueous and methanolic extracts of propolis (Apis mellifera L.) from Algarve, South Portugal." Food Science and Technology 34.1 (2014): 16-23.
20. Midorikawa, K., Banskota, A. H., Tezuka, Y., Nagaoka, T., Matsushige, K., Message, D., & Kadota, S. (2001). Liquid chromatography–mass spectrometry analysis of propolis. Phytochemical Analysis: An International Journal of Plant Chemical and Biochemical Techniques, 12(6), 366-373.
21. .Ebrahimzadeh, M. A., Pourmorad, F., & Bekhradnia, A. R. (2008). Iron chelating activity, phenol and flavonoid content of some medicinal plants from Iran. African journal of Biotechnology, 7(18).
22. Magaldi, S., Mata-Essayag, S., De Capriles, C. H., Pérez, C., Colella, M. T., Olaizola, C., & Ontiveros, Y. (2004). Well diffusion for antifungal susceptibility testing. International journal of infectious diseases, 8(1), 39-45.
23. Valgas, C., Souza, S. M. D., Smânia, E. F., & Smânia Jr, A. (2007). Screening methods to determine antibacterial activity of natural products. Brazilian journal of microbiology, 38, 369-380.
24. Wagh, V. D. (2013). Propolis: a wonder bees product and its pharmacological potentials. Advances in Pharmacological and Pharmaceutical Sciences, 2013(1), 308249.
25. Ahmed, R., Tanvir, E. M., Hossen, M. S., Afroz, R., Ahmmed, I., Rumpa, N. E. N., ... & Khalil, M. I. (2017). Antioxidant properties and cardioprotective mechanism of Malaysian propolis in rats. Evidence‐Based Complementary and Alternative Medicine, 2017(1), 5370545.
26. Alfarrayeh, I. I. S. (2021). Bioactivities and potential beneficial properties of propolis ethanolic extract, caffeic acid phenethyl ester, and Arabic coffee beans extract. University of Pécs Pécs, Hungary.
27. Martinotti, S., & Ranzato, E. (2015). Propolis: a new frontier for wound healing?. Burns & trauma, 3, 1-7.
28. Galeotti, F., Maccari, F., Fachini, A., & Volpi, N. (2018). Chemical composition and antioxidant activity of propolis prepared in different forms and in different solvents useful for finished products. Foods, 7(3), 41.
29. Paviani, L. C., Fiorito, G., Sacoda, P., & Cabral, F. A. (2013, April). Different solvents for extraction of Brazilian green propolis: Composition and extraction yield of phenolic compounds. In III Iberoamerican Conference on Supercritical Fluid (pp. 1-5).
30. Kubiliene, L., Laugaliene, V., Pavilonis, A., Maruska, A., Majiene, D., Barcauskaite, K., ... & Savickas, A. (2015). Alternative preparation of propolis extracts: comparison of their composition and biological activities. BMC complementary and alternative medicine, 15, 1-7.
31. Sun, C., Wu, Z., Wang, Z., & Zhang, H. (2015). Effect of ethanol/water solvents on phenolic profiles and antioxidant properties of Beijing propolis extracts. Evidence‐Based Complementary and Alternative Medicine, 2015(1), 595393.
32. Kara, Y., Can, Z., & Kolaylı, S. (2022). What should be the ideal solvent percentage and solvent-propolis ratio in the preparation of ethanolic propolis extract?. Food Analytical Methods, 15(6), 1707-1719.
33. Mulyati, A. H., Sulaeman, A., Marliyati, S. A., Rafi, M., & Fikri, A. M. (2020, June). Phytochemical analysis and antioxidant activities of ethanol extract of stingless bee propolis from Indonesia. In AIP Conference Proceedings (Vol. 2243, No. 1). AIP Publishing.
34. Kumar, N., Ahmad, M. K. K., Dang, R., & Husain, A. (2008). Antioxidant and antimicrobial activity of propolis from Tamil Nadu zone. Journal of Medicinal Plants Research, 2(12), 361-364.
35. Sowmya, S., Gujjari, A. K., Mruthunjaya, K., Padmanabhan, T. V., Anupama, C., Sushma, R., & Gaekwad, S. S. (2019). Antioxidant and antimicrobial activity of propolis.
36. Park, Y. K., & Ikegaki, M. (1998). Preparation of water and ethanolic extracts of propolis and evaluation of the preparations. Bioscience, biotechnology, and biochemistry, 62(11), 2230-2232.
37. Sokolonski, A. R., Fonseca, M. S., Machado, B. A. S., Deegan, K. R., Araújo, R. P. C., Umsza-Guez, M. A., & Portela, R. W. (2021). Activity of antifungal drugs and Brazilian red and green propolis extracted with different methodologies against oral isolates of Candida spp. BMC complementary medicine and therapies, 21, 1-14.
38. Dönmez, M., Karadeniz, Ş., Yoldas, T., Aydın, G., Karagül, P., Aksu, O., & Rasgele, P. G. (2020). Comparison of chemical contents of extracts in different solvents of propolis samples produced in Duzce province. International Journal of Traditional and Complementary Medicine Research, 1(3), 137-146.
39. https://www.iitb.ac.in
Published
2024-09-07
How to Cite
Charushila papal, & Dr Rohini patil. (2024). Indian Propolis: Chemical Composition, Antioxidant and Antimicrobial Properties. Revista Electronica De Veterinaria, 25(1S), 688-694. https://doi.org/10.69980/redvet.v25i1S.828
Section
Articles
