Preparation And Evaluation Of Polyherbal Formulation For Inflammation Management
Keywords:
Polyherbal, total phenolic, albumin denaturation, anti-inflammatory, flow property
Abstract
Trigonellafoenum-graecum seed (TFG), Zingiber officinale rhizome (ZO) and Cissus quadrangularis stem (CQ) were extracted using purified water and mixed in equal ratio to obtain a polyherbal formulation. The extraction yield for TFG, ZO and CQ were found to be 11.8, 10.2 and 13.4% respectively. The total phenolic content in TFG, ZO and CQ extracts were found to be 36.2137.91 and 30.26 GAE mg/100g respectively. The angle of repose of the polyherbal formulation was found to be 26°18’ with compressibility index of 18.07% and Hausner ratio of 1.22. The formulation was able to inhibit 54.81% denaturation of albumin at 1000mM concentration suggesting significant anti-inflammatory action.
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2. Grosser T, Smyth EM, FitzGerald GA. Pharmacotherapy of inflammation, fever, pain and gout. In: Goodman and Gilman’s The pharmacological basis of therapeutics. 13th ed. McGraw Hill Education, New York, 2016; pp 685-709
3. Yoganarsimhan SN. Medicinal plants of India. Cyber Media Bangalore 2, 2000; 2:136–137.
4. Mishra G, Srivastava S, Nagori BP. Pharmacological and therapeutic activity of Cissusquadrangularis: An overview. International Journal of PharmTech Research 2010; 2(2):1298-1310.
5. Goyal S, Gupta N, Chatterjee S. Investigating therapeutic potential of Trigonellafoenum-graecum L. as our defense mechanism against several human diseases. Journal of Toxicology 2016; http://dx.doi.org/10.1155/2016/1250387
6. Ghasemzadeh A, Jaafar HZE, Rahmat A. Antioxidant activities, total phenolics and flavonoids content in two varieties of Malaysia young ginger (Zingiberofficinale Roscoe). Molecules 2010; 15: 4324-4333
7. SahiraBanu K, Cathrine L. General Techniques Involved in Phytochemical Analysis. International Journal of Advances Research in Chemical Sciences 2015; 2(4): 25-32
8. Chanthasri W, Puangkeaw N, Kunworarath N, Jaisamut P, Limsuwan S, Maneenoon K, Choochana P, Chusri S. Antioxidant capacities and total phenolic contents of 20 polyherbal remedies used as tonics by folk healers in Phatthalung and Songkhla provinces, Thailand. BMC Complementary and Alternative Medicine 2018; 18:73. https://doi.org/10.1186/s12906-018-2131-y
9. Ahmed AAAJ, Pandey GK, Dubey BK. Formulation and evaluation of polyherbal capsules for the management of gout. Journal of Pharmacology and Biomedicine. 2021; 5(1): 249-258.
10. Singh AP, Mishra B. Evaluation of anti-inflammatory potential of Rutin using in vitro models. Journal of Pharmacology and Biomedicine. 2020; 4(1): 211-217
Published
2024-10-14
How to Cite
Rashmi Pathak, Prabhakar Singh Tiwari, & Surya Prakash Gupta. (2024). Preparation And Evaluation Of Polyherbal Formulation For Inflammation Management. Revista Electronica De Veterinaria, 25(2), 19-22. https://doi.org/10.69980/redvet.v25i2.1202
Section
Articles
