Study of the effect of cancer antigen CA15-3 and CRP on Liver enzymes and Kidney function in patients with breast cancer in Al-Muthanna Governorate
Keywords:
Breast cancer, CA15-3, CRP, Liver enzymes, Kidney function
Abstract
This study was conducted in the laboratories of Al-Hussein Teaching Hospital and some private laboratories in the city of Samawah in Al-Muthanna Governorate for a period from 1/15/2024 to 3/15/2024. The study included (80) samples of women of reproductive age, ranging in age from (25-70). year, and were divided into two groups:
- Patient group: (40) samples of patients with breast cancer.
- Control group: (40) samples of healthy women.
The pathological cases of women with breast cancer were confirmed after conducting clinical examinations and referring them to the specialist doctor and performing an ultrasound examination. After that, blood was taken from both groups (patients and healthy people) and separated using a centrifuge. Then the level of cancer antigen was measured. CA15-3 and CRP to confirm whether they have breast cancer, in addition to measuring immune and physiological variables. The results of the current study showed a significant increase in each of the diagnostic indicators, liver enzymes, and kidney functions in the blood serum of both groups, at a level of probability P ≤ 0.05.
References
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33. AL- Hussein, Saja Abdul-Qader Hussein, Evaluation of the Serum Levels of Alanine Aminopeptidase and Aggrecan with Some Biochemical Parameters in Women with Breast Cancer, Degree of Master, Tikrit University, College of Medicine. 2019.
34. Chauhan P, Yadav R, Kaushal V, Beniwal P. Evaluation of serum biochemical profile of breast cancer patients. Int J Med Res Health Sci. 2016;5(7):1.
35. Nandhini , Thasleema; PRIYA, Jothi; DEVI, R. Gayatri. Biochemical evaluation of patients with breast cancer. Drug Invention Today, 2019, 11.8
36. Devi LI, Ralte L, Ali MA. Serum biochemical profile of breast cancer patients. European Journal of Pharmaceutical and Medical Research. 2015;2(6):210-4.
37. Abou Zaid OA, Ahmed FA, Badwi AF, Ibrahim NM. Effect of natural nanoparticles products on hepato-renal functions in breast carcinoma female rats. Benha Veterinary Medical Journal. 2017;33(2):99-106.
38. Aapro M, Launay-Vacher V. Importance of monitoring renal function in patients with cancer. Cancer treatment reviews. 2012;38(3):235-40.
39. Stabuc B, rhovec L, tabuc- ilih M, Cizej TE. Improved prediction of decreased creatinine clearance by serum cystatin C: use in cancer patients before and during chemotherapy. Clinical chemistry. 2000;46(2):193-7.
40. Aoki M, Terada T, Kajiwara M, Ogasawara K, Ikai I, Ogawa O, Katsura T, Inui KI. Kidney-specific expression of human organic cation transporter 2 (OCT2/SLC22A2) is regulated by DNA methylation. American Journal of Physiology-Renal Physiology. 2008;295(1):F165-70. 234.
2. Kolak A, Kamińska M, Sygit K, et al . Primary and secondary prevention of breast cancer. Ann Agric Environ Med. 2017;24(4):549-53.
3. Alwan NA. Breast cancer among Iraqi women: Preliminary findings from a regional comparative Breast Cancer Research Project. Journal of global oncology. 2016;2(5):255.
4. Alwan, N.A.;Tawfeeq. F. N. and Mallah, A. S; &Har,S.A and Saleh W.A.The stay Demographic and clinical profiles of female patients diagnosed with breast cancer in Iraq. Journal of Contemporary Medical Sciences, 2019 ;5(1):14-19.
5. Lacroix, Marc. "Significance, detection and markers of disseminated breast cancer cells." Endocrine-related cancer 13.4 (2006): 1033-1067.
6. Eltayeb, Toga Farag. Detection of breast cancer using artificial neural networks (ANN). Diss. Sudan University of Science and Technology, 2014.
7. Shyyan, R., Masood, S., Badwe, R. A., Errico, K. M., Liberman, L., Ozmen, V.& Global Summit Diagnosis and Pathology Panel. Breast cancer in limited‐resource countries: diagnosis and pathology. The breast journal, 2006; 12, S27-S37.
8. Maric, P.; Ozretic, P.; Levanat, S. et al. Tumor markers in breast cancer-evaluation of their clinical usefulness. Coll Antropol. 2011;35(1):241-7.
9. Werner, M.; Faser, G. and Silverbery. Clinical utility and validation of emerging biochemical marker for mammary adenocarcinoma. J. Clin. Chem. 1993;39(11):2386-96.
10. Tondini, C.; Hayes, D.F. and Gelman, R. Use of various epithelial tumor marker and stromal marker in assessment of cervical carcinoma obstet. J. Gynecol. 1991; 77:566.
11. Newburgh JD. The changes which alter renal osmotic work. The Journal of clinical investigation .1943; 22(3): 439-446.
12. Wallace MA. Anatomy and physiology of the kidney. AORN journal .1998; 68(5):799-820.
13. Matsue, Y., van der Meer, P., Damman, K., et al . Blood urea nitrogen-to-creatinine ratio in the general population and in patients with acute heart failure. Heart 2017; 103: 407–413.
14. Qian, H., Tang, C., Yan, G., Predictive value of blood urea nitrogen/creatinine ratio in the long-term prognosis of patients with acute myocardial infarction complicated with acute heart failure. Medicine (Baltimore). Medicine (Baltimore). 2019;98(11): 14845.
15. Lim, Andy KH. "Abnormal liver function tests associated with severe rhabdomyolysis." World journal of gastroenterology . 2020; 26.10: 1020.
16. Madhuri, D. and Viveka, V. V. Alkaline and acid phosphatase levels in the abdominal muscles of immune stimulated mice during hepatitis B. Biolife. 2014;2: 400.
17. Masuda A, Yoshida M, Shiomi H, Morita Y, Kutsumi H, Azuma T. Role of Fc Receptors as a Therapeutic Target Role of Fc Receptors as a Therapeutic Target. Journal of Pharmaceutical University, Japan 2014; 11(32014); 1–7.
18. CaoW, Vrees MD, Kriber MT, Fiocchi C, Pricolo VE. Hydrogen peroxide contributes to motor dysfunction in ulcerative colitis .Amj physiol Gastr. Liver physiol 2004;288(5):833-43.
19. Mohammed , F. Z. Lamis Gamal , Mohamed Farouk Mosa, Mohamed Ibraheim Aref .Assessment of CA15-3 and CEA as Potential markers for Breast carcinoma prognosis in Egyptian Females. AJBAS Volume 2, Issue 1, 2021.
20. Hamdi .E. T , Alsamarai A.T, Ali . A.A . The relationship between vitamin D with breast Cancer. Medical Science. 24(104).2020.
21. Feng, Z.; Li, J.; Liu, L.; Wang, X.; Huang, Y.; Dai, H. et al. Tumor markers CA15-3, CA125, CEA and breast cancer survival by molecular subtype: a cohort study. Breast Cancer2020; 1-10.
22. Braihan Hamdi Hameed 1*, Izzat Abdulsatar Al-Rayahi1, Salwa S. Muhsin2 166- Evaluation of Preoperative CA15-3 Level and its Relationship with Clinico-Pathological Characteristics in Primary Breast Cancer Patients Journal of Techniques, ISSN: 2708-8383, Vol. 4, No. 2, June 30, 2022, Pages 21-26.
23. Huda Hameed Othman(MBChB) 1 , Walaa Najm Abood (PhD) 2 and Nazar Abdul Hassan Alwakeel (FICM) The level of serum Tumor Marker CA15-3 in women with Breast Cancer. Diyala Journal of Medicine. 2018; 15 1 .
24. Panis, C., et al. "Differential oxidative status and immune characterization of the early and advanced stages of human breast cancer." Breast cancer research and treatment 133.3 (2012): 881-888.
25. Allin, Kristine H., et al. "Elevated pre-treatment levels of plasma C-reactive protein are associated with poor prognosis after breast cancer: a cohort study." Breast Cancer Research 13.3 (2011): 1-13.
26. Celik, Betul, et al. "CXCL8, IL-1β and sCD200 are pro-inflammatory cytokines and their levels increase in the circulation of breast carcinoma patients." Biomedical reports 5.2 (2016): 259-263.
27. Asegaonkar, Shilpa Balaji, et al. "C-reactive protein and breast cancer: new insights from old molecule." International journal of breast cancer 2015 (2015).
28. Guo, Lanwei, et al. "C-reactive protein and risk of breast cancer: A systematic review and meta-analysis." Scientific reports 5.1 (2015): 1-8.
29. Thornburg, J.M.; Nelson, K. K.; Clem, B. F.; Lane, A. N.; Arumugam, S.; Simmons, A. et al. Targeting aspartate aminotransferase in breast cancer. Breast Cancer Research,2008; 10(5): R84.
30. i ici, .; Ozgurog u, M.; Mihm ı, İ.; Tur , H. t i, İ. case–control study of non-alcoholic fatty liver disease in breast cancer. Medical Oncology. 2007; 24(4), 367–371.
31. Ashtee A. Ahmad', Kamaran Abdoulrahman. Effect of oxidative stress on tumor suppressor protein p53 and some biochemical markers in breast cancer patients in Erbil governorate. ISSN (print :2218-1230, ISSN (anline): 2412-3986.
32. Korangath, P.; Teo, W. W.; Sadik, H.; Han, L.; Mori, N.; Huijts, C. M. et al. Targeting Glutamine Metabolism in Breast Cancer with mi ooxy c t t . i ic c r R s rch : Official Journal of the American Association for Cancer Research. 2015; 21(14): 3263-3273
33. AL- Hussein, Saja Abdul-Qader Hussein, Evaluation of the Serum Levels of Alanine Aminopeptidase and Aggrecan with Some Biochemical Parameters in Women with Breast Cancer, Degree of Master, Tikrit University, College of Medicine. 2019.
34. Chauhan P, Yadav R, Kaushal V, Beniwal P. Evaluation of serum biochemical profile of breast cancer patients. Int J Med Res Health Sci. 2016;5(7):1.
35. Nandhini , Thasleema; PRIYA, Jothi; DEVI, R. Gayatri. Biochemical evaluation of patients with breast cancer. Drug Invention Today, 2019, 11.8
36. Devi LI, Ralte L, Ali MA. Serum biochemical profile of breast cancer patients. European Journal of Pharmaceutical and Medical Research. 2015;2(6):210-4.
37. Abou Zaid OA, Ahmed FA, Badwi AF, Ibrahim NM. Effect of natural nanoparticles products on hepato-renal functions in breast carcinoma female rats. Benha Veterinary Medical Journal. 2017;33(2):99-106.
38. Aapro M, Launay-Vacher V. Importance of monitoring renal function in patients with cancer. Cancer treatment reviews. 2012;38(3):235-40.
39. Stabuc B, rhovec L, tabuc- ilih M, Cizej TE. Improved prediction of decreased creatinine clearance by serum cystatin C: use in cancer patients before and during chemotherapy. Clinical chemistry. 2000;46(2):193-7.
40. Aoki M, Terada T, Kajiwara M, Ogasawara K, Ikai I, Ogawa O, Katsura T, Inui KI. Kidney-specific expression of human organic cation transporter 2 (OCT2/SLC22A2) is regulated by DNA methylation. American Journal of Physiology-Renal Physiology. 2008;295(1):F165-70. 234.
Published
2024-11-26
How to Cite
Ali moaid raheem fadil abokhila, & Dr.Seyyed Meisam Abtahi. (2024). Study of the effect of cancer antigen CA15-3 and CRP on Liver enzymes and Kidney function in patients with breast cancer in Al-Muthanna Governorate. Revista Electronica De Veterinaria, 25(2), 476 - 482. https://doi.org/10.69980/redvet.v25i2.1406
Section
Articles
