“Evaluation Of Langerhans Cells Using Cd1a In Oral Submucous Fibrosis: An Immunohistochemical Study”
Abstract
The burden of cancer is still increasing worldwide despite advances for diagnosis and treatment. Epidemiological studies have shown that many cancers may be avoidable. It is widely held that 80–90% of human cancers may be attributable to environmental and lifestyle factors such as tobacco, alcohol and dietary habits. It was estimated that in the year 2000, worldwide over 10 million new cases of cancer occurred (approximately 5.3 million men and 4.7 million women) and over 6 million people died from cancers.
This study aims to evaluate the presence of langerhans cells in various histological stages of OSMF using CD1a antibody, which has been suggested as the most reliable marker of langerhans cells differentiation & to determine whether alterations in the number of LCs impairs oral mucosal immunologic protection against mutagens such as
areca nut (betel quid), tobacco constituents, which might play a role in oral epithelial dysplasia& oral squamous cell carcinoma.
References
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2. SamanWarnakulasuriya. Global epidemiology of oral and oropharyngeal cancer. Oral Oncology 2009; 45: 309–316.
3. S. EL Mofty. Early detection of oral cancer .Egypt. J. Oral Maxillofac. Surg. 2010; 1: 25- 31.
4. Crispian Scully, José V. Bagan, Colin Hopper, &Joel B. Epstein. Oral cancer: Current and future diagnostic techniques.Am J Dent 2008;21:199-209.
5. R.B. Zain, N. Ghazali. A review of epidemiologicalstudies of oral cancer andprecancer in Malaysia. Annal Dent Univ Malaya 2001; 8: 50-56.
6. Chris de Souza, UdayPawar, PankajChaturvedi. Precancerous lesions of oral cavity.Otolaryngeology Clinics: An International Journal May- Sept 2009; 1(1):7-14.
7. R. Rajendran. Oral submucous fibrosis: etiology,pathogenesis, and future research. WHO Bulletin OMS 1994; 72.
8. GanigaChannaiahShivakumar, ShivakumarSahana. Correlation between the Functional and Histological Staging of Oral Submucous Fibrosis. Journal of Indian Academy of Oral Medicine and Radiology, July-September 2010;22(3):133-135.
9. Ahmad M. S., Ali S. A., Ali A. S., Chaubey K. K. Epidemiological and etiological study of oral submucous fibrosis among Gutka chewers of Patna, Bihar, India. J Indian SocPedodPrev Dent - June 2006; 84-89.
10. R. Rajendran, G.K. Raju, S.M. Nair,& G. Balasubramanian. Prevalence of oral submucous fibrosis in thehigh natural radiation belt of Kerala, South India. Bulletin of the World Health Organization, 1992;70(6): 783-789.
11. Vanaja Reddy, P.V.Wanjari, Naveen Reddy Banda, Prashanti Reddy. Oral Submucous Fibrosis: Correlation of Clinical Grading to various habit factors. International Journal Of Dental Clinics 2011:3(1).
12. AjitAuluck, Miriam P. Rosin, Lewei Zhang, Sumanth KN. Oral Submucous Fibrosis, a Clinically Benignbut Potentially Malignant Disease:Report of 3 Cases and Review of the Literature. October 2008; 74(8) .
13. Saba Khan, LaxmikantChatra, Shenai KP, K M Veena, Prasanna Kumar Rao. Pathogenesis of oral submucous fibrosis. Journal of Cancer Research and Therapeutics- April- June 2012; 8(2): 199-203.
14. N. Afroz, S.A. Hasan, S. Naseem. Oral Submucous Fibrosis A Distressing Disease with Malignant Potential. Indian Journal of Community Medicine October-December 2006; 31(4): 270-271.
15. Chung-Jung Chiu, Min-Lee Chang, Chun-Pin Chiang,Liang-Jiunn Hahn, Ling-Ling Hsieh, and Chien-Jen Chen. Interaction of Collagen-related Genes and Susceptibility to BetelQuid-induced Oral Submucous Fibrosis. Cancer Epidemiology, Biomarkers & Prevention- July 2002;11: 646–653.
16. RamachandranSudarshan, Rajeshwari G Annigeri, SreeVijayabala G. Pathogenesis of Oral Submucous Fibrosis: The Past and Current Concepts. International Journal of Oral & Maxillofacial Pathology. 2012;3(2):27-36.
17. C.P. Chiang, H.Y. Wu, B.Y. Liu, J.T. Wang, M.Y.P. Kuo. Quantitative analysis of immunocompetent cells in oral submucousfibrosis in Taiwan. Oral Oncol 2002; 38: 56–63.
18. Anjali Narwal&SusmitaSaxena: A comparison of langerhans cell numbers in tobacco-associated leukoplakia& oral squamous cell carcinoma. Int J Oral –Med 2011; 10(3):125-131.
19. Kalpana A P, Rajkumar N P, Sangeeta PW. Correlation of salivary and serum IgG, IgA levels with total protein in oral submucous fibrosis. Jr of Oral Science 2011; 53(1): 97-102.
20. Pindborg JJ, Sirsat SM. Oral Submucous Fibrosis. Oral Surg, Oral Med, Oral Pathol 1966; 22(6): 764-779.
21. P. C. Gupta, p. N. Sinor, r. B. Bhonsle, v. S. Pawar, h. C. Mehta. Oral submucous fibrosis in India: A new epidemic? The national medical journal of india 1998; 11(3): 113-116.
22. Pindborg, J. J., Chawla, T. N., Shrivastava, A. N., Gupta, D. &MehrotraSubmucous Fibrosis of the Oral Cavity : 2. Studies on Epidemiology .Actaodont. scand.1964; 22: 793-799.
23. Peter A. Hayes. Oral submucous fibrosis in a 4-year-old girl. Oral Surg, Oral Med, Oral Pathol 1985; 59(5): 475-478.
24. . Fali S. Mehta, Gupta, J. J. Pindborg, R. B. Bhonsle,P. N. Jalnawalla, & P. N. Sinor. An intervention study of oral cancer and precancerin rural Indian populations: a preliminary report. Bulletin of the World Health Organiztion 1982; 60(3): 441-446.
25. Pindborg JJ. Oral Submucous Fibrosis: A Review. Annals of the Academy of Medicine, Singapore1989; 18(5):603-607].
26. Nektorios IL. OraSubmucous Fibrosis. http://www.emedicine,com/derm/topic 653. htm (1 of 19) 10/2/2007.
27. Prakash C Gupta. Areca nut use in India. Indian J Med Science 2007; 61: 317-319.
28. P. N. Sinor, P. C. Gupta, P. R. Murti, R. B. Bhonsle, D. K. Daftary, Mehta, J. J. Pindborg. A case-control study of oral submucous fibrosis with special reference to the etiologic role of areca nut. Journal of Oral Pathology & Medicine 1990; 19(2):94–98.
29. Binu J Jacob, Kurt Straif, Gigi Thomas, KunnambathuRamadas, Babu Mathew, Zuo-Feng Zhang, RengaswamySankaranarayanan, Mia Hashibe. Betel quid without tobacco as a risk factor for oral precancers. Oral Oncol2004; 40: 697–704.
30. A. Ariyawardana, A. D. S. Athukorala, A. Arulanandam. Effect of betel chewing, tobacco smoking and alcohol consumption on oral submucous fibrosis: a case–control study in Sri Lanka.Jr of Oral Pathol& Med April 2006; 35(4): 197–201.
31. W.M. Tilakaratne, Klinikowski, Takashi Saku, T.J. Peters, SamanWarnakulasuriya. Oral submucous fibrosis: Review on aetiology and pathogenesis. Oral Oncol 2006; 42: 561– 568.
32. Soma Babu, Ramesh VenkataramanaBhat, PutchaUday Kumar, BoindalaSesikaran, KakarapartiVisweswaraRao, PakerlaAruna and Puttam Reddy Ramachandra Reddy. A Comparative Clinico-Pathological Study of Oral Submucous Fibrosis in Habitual Chewers of Pan Masala and Betelquid. Clinical Toxicology 1996, Vol. 34, No. 3 , Pages 317-322.
33. N. Shah, P. P. Sharma. Role of chewing and smoking habits in the etiology of oral submucous fibrosis (OSF): a case-control study. Jr of Oral Pathol& Med- November 1998; 27(10): 475–479.
34. Mohammad Sami Ahmad, ShariqueAther Ali, Ayesha Sharique Ali, Krishna Kumar Chaubey. Comparative Severity of Oral Submucous Fibrosis among gutkha and other areca nut products chewers. http://www.priory.com/den/areca.htm (2 of 20) 10/2/2007.
35. Saraf S. Textbook of Oral Pathology. 1st edition 2006; Jaypee Publishers.
36. Yu-Chao Changa, Shun-FaYangb, Kuo-Wei Taia, Ming-Yung Chouc, Yih-Shou Hsieh. Increased tissue inhibitor of metalloproteinase-1 expression and inhibition of gelatinaseA activity in buccal mucosal fibroblasts by arecoline as possible mechanisms for oral submucous fibrosis. Oral Oncol 2002; 38: 195–200.
37. Chung-Hung Tsai, Shun-Fa Yang, Yu-Chao Chang. The upregulation of cystatin C in oral submucous fibrosis. Oral Oncol 2007; 43: 680– 685.
38. Supriya S Koshti, Suresh Barpande. Quantification of plasma fibrinogen degradation products in oral submucous fibrosis: A clinicopathologic study J Oral MaxillofacPathol 2007;11: 48-50.
39. Harvey W, Scutt A, Meghji S, Canniff JP. Stimulation of human buccal mucosa fibroblasts in vitro by betel-nut alkaloids. Arch Oral Biol. 1986;31(1):45-9.
40. Van Wyk CW, Stander I, Padayachee A, Grobler-Rabie AF: The areca nut chewing habit and oral squamous cell carcinoma in South African Indians. A retrospective study. S Afr Med J 1993 Jun; 83(6): 425-9.
41. Haque MF, Meghji S, Khitab U, Harris M. Oral submucous fibrosis patients have altered levels of cytokine production. J Oral Pathol Med 2000: 29: 123–8.
42. Rajalalitha P, Vali S. Molecular pathogenesis of oral submucous fibrosis – a collagen metabolic disorder. J Oral Pathol Med 2005; 34: 321–328.
43. Tsai CC, Ma RH, Shieh TY. Deficiency in collagen and fibronectin phagocytosis by human buccal mucosa fibroblasts in vitro as a possible mechanism for oral submucous fibrosis. J Oral Pathol Med 1999; 28:59–63.
44. Shieh DH, Chiang LC, Lee CH, Yang YH, Shieh TY. Effects of arecoline, safrole and nicotine on collagen phagocytosis by human buccal mucosal fibroblasts as a possible mechanism for oral submucous fibrosis in Taiwan. J Oral Pathol Med 2004; 33: 581–587.
45. Shieh DH, Chiang LC, Shieh TY. Augmented mRNA expression of tissue inhibitor of metalloproteinase1 in buccal mucosal fibroblasts by arecoline and safrole as a possible pathogenesis for oral submucous fibrosis. Oral Oncol 2003; 39: 728–735.
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Published
2024-08-31
How to Cite
Dr.Sourab Kumar, Dr.Abhishek Jadhav, Dr. Sejal Vijay Palve, Dr. Nisha Kumari Jaiswal, Dr. Saniya Subir Puthanpurakkal, & Dr. Priyanka Anil Patil. (2024). “Evaluation Of Langerhans Cells Using Cd1a In Oral Submucous Fibrosis: An Immunohistochemical Study”. Revista Electronica De Veterinaria, 25(2), 1939-1963. https://doi.org/10.69980/redvet.v25i2.2034
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