In Situ Gels- A Novel Approach For Ophthalmic Drug Delivery System
Abstract
Ophthalmic drug delivery is a fascinating and challenging endeavour for pharmaceutical scientists. Traditional ocular drug delivery systems such as solutions, suspensions, and ointments have drawbacks such as increased precorneal elimination, high variability in efficiency, and blurred vision, so an advanced drug delivery system was developed. To overcome the drawbacks of traditional drug therapy, in situ forming polymeric formulations were developed. These systems are in solution form before being administered in the body, but once administered, these systems gel. Gel formation is influenced by factors such as changes in a specific physicochemical parameter (pH, temperature, ion-sensitive) that allows the drug to be released in a sustained and controlled manner. Drug content, clarity, pH, gelling capacity, viscosity, in vitro drug release tests, texture analysis, sterility testing, isotonicity evaluation, accelerated studies, and irritancy test were all tested for these systems. To determine the compatibility of drugs and polymers, FT-IR spectroscopy was performed.
References
2. Patel P.B. Shastri D.H. Shelat P.K. and Shukla A.K. Development and Evaluation of PH Triggered In situ Ophthalmic Gel Formulation of Ofloxacin, Am. J. Pharm. Tech. Res., 2011, 1(4):430-445.
3. Zarikar N. Katedeshmukh R. Kulkarni A. and Patel R. Ophthalmic In situ Drug Delivery System: A Review, Int. J. Pharm. Res. & Dev., 2013, 5(5):48 – 55.
4. Talat F. Sadhana R.S. Azmat M.S. Nityanand Z. and Syed A. Formulation Development and Evaluation of In situ Ophthalmic Gel of Sodium Cromoglycate. Der Pharmacia Sinica, 2013, 4(2):109-118.
5. Gupta A. and Manocha N. Formulation and Evaluation of In Situ Ophthalmic Drug Delivery System, Int. J. Pharm. Bio. Arch., 2012, 3(4):715-718.
6. Agarwal K. Mehta N. Namdev A. and Gupta A.K. In Situ Gel Formation for Ocular Drug Delivery System: An Overview, Asian J. Bio Pharm Sci., 2011, 1(4):01-07.
7. Rajeshwari N. Patil R. and Kumar S. In situ Gelling System: Novel Approach for Ophthalmic Drug Delivery, World J. Pharm. Pharma. Sci. 2014, 3(7):423-440.
8. Nittur J. R. kunchu k. Theetha G. and Tamizh M. Review on In situ Ophthalmic Gels: A Developing Trend, Int. J. Pharma. Sci. Rev. & Res., 2011, 7(1):08-14.
9. Parekh H.B. Rishad J. Jivani N.P. Patel L.D. Makwana A and Sameja K. Novel In situ Polymeric Drug Delivery System: A Review, J.Drug Deliv. & Therap., 2012, 2(5):136-145.
10. Nirmal H.B. Bakliwal S.R. and Pawar S.P. In Situ Gel: New Trends in Controlled and Sustained Drug Delivery System, Int. J. Pharm. Tech. Res., 2010, 2(2):1398-1408.
11. Nerkar T.S. Gujarathi N.A. Bhushan R. Bakliwal S. R. and Pawar S.P. In situ Gel: Novel Approach in Sustained and Controlled Drug Delivery System, Pharma. Sci. monitor, 2013, 4(4):1-18.
12. Rajoia G and Gupta A. In situ Gelling System: A Novel Approach for Ocular Drug Delivery, Am. J. Pharm. Tech. Res., 2012, 2(4):25- 53.
13. Rathore K.S. In situ Gelling Ophthalmic Drug Delivery System: An Overview, Int. J. Pharm. Pharm. Sci., 2011, 2(4):30¬34.
14. Bhardwaj L. Sharma P. K. and Malviya R. A Short Review on Gastro Retentive Formulations for Stomach Specific Drug Delivery: Special Emphasis on Floating In situ Gel Systems, African J. Basic & Applied Sci., 2011,3(6): 300-312.
15. Sampathi S. Design, Development and Characterization: In situ Gels of Lomefloxacin Hydrochloride for Ocular Drug Delivery, World J. Pharm. Pharma. Sci., 2014, 3(2):2350-2364.
16. Vengurlekar P. Singh A. and Rathod S. Microspheric In situ Gel for Ocular Drug Delivery System of Bromfenac Sodium, Int. J. Pharma. Sci. Res., 2014, 5(4):179-185.
17. Gambhire S. bhalerao K. and Singh S. Review on In situ Hydrogel: Different Approaches to Ocular Drug Delivery, Int. J. Pharm. Pharm. Sci.,2013,5(2):27-36.
