A Critical Review Of Dushi-Visha In The Pathogenesis Of Chronic Eczema And Psoriasis
Abstract
The escalating global prevalence of chronic inflammatory skin disorders, such as psoriasis and chronic eczema, has necessitated a deeper exploration into their underlying etiopathological mechanisms, beyond mere genetic and local inflammatory factors. In the profound architectural framework of Ayurvedic medicine, these conditions are frequently recalcitrant due to the presence of Dushi-visha a latent, cumulative toxin sequestered within the tissues, resisting conventional therapeutic interventions. This research paper provides an exhaustive critical review of the role of Dushi-visha in the pathogenesis of chronic eczema and psoriasis, drawing parallels between ancient toxico-pathological concepts and modern dermatological findings. By analyzing the ten classical properties of Visha and their attenuation into a latent state, this study elucidates how environmental pollutants, xenobiotics, and incompatible dietary patterns (Viruddhahara) act as modern incarnations of Dushi-visha. The research highlights the specific vitiation of Rakta Dhatu (blood tissue) and the subsequent manifestation of Kitibha (Psoriasis) and Vicharchika (Eczema). Through a detailed examination of the IL-23/IL-17 axis and Th2-mediated inflammatory pathways in conjunction with Ayurvedic Samprapti (pathogenesis), the paper establishes a unique integrative model. Furthermore, the therapeutic efficacy of Shodhana (purification) and the herbo-mineral formulation Dushi-vishari Agada are analyzed as targeted interventions to neutralize these deep-seated toxins. This review concludes that the management of chronic dermatoses must shift from symptomatic suppression to the fundamental elimination of cumulative toxicity.
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