The Benefits of β-Glucan Injection during Suckling: Enhancing Immune Responses and Intestinal Health in Newly Weaned Rabbits

  • Sujayaraj S Assistant Professor, Department of Forensic Science, School of Sciences, JAIN (Deemed-to-be University), Karnataka, Bangalore, India
  • Smita Sarma Assistant Professor, Department of Biotechnology, Assam down town University, Guwahati, Assam, India
  • S.K. Khatik Assistant Professor, School of Agricultural Sciences, Jaipur National University, Jaipur, Rajasthan, India
Keywords: Beta-glucans, Weaned Rabbits, genes, DNA, vaccination


The rabbits that have just been weaning are vulnerable to erratic infectious agents, which frequently cause diarrhoea. Natural immunity can also be educated, according to recent research. A quicker and more potent immune response to both homolog and heterogeneous recurrence is a crucial component of acquired immunity. As a result, the current study examined the process of diarrhoea protection provided by intraperitoneal administration of Beta-glucan during the nursing period in weaned rabbits. Sixty-four nursing rabbits were randomly divided into the control group (C) and the trained group (T), according to bodyweight and breed. Physiological saline solution (PSS) and Beta-glucan dissolved in PSS were intraperitoneally administered into the rabbits in the two groups at 6 and 4 days prior to weaning, respectively. Two weeks after weaning, 1 5 rabbits from every group were selected at random for sampling. The trained group's crypt depth and diarrhoea rate were shown to be lower (P 0.04 or P 0.02) in the results. Tumour necrosis factor-alpha (TNF-alpha) and interleukin-15 (IL-10) gene expression increased while interleukin-65(IL-5) gene expression decreased in rabbits receiving Beta-glucan during suckling when compared to the control group (P 0.01). Following weaning, pre-stimulation with Beta-glucan also enhanced the content of ileal secretory immunoglobulin (sIgA) and lysozyme (LYZ) as well as serum immunoglobin A (IgA) and G (IgG) (P 0.04). Additionally, the trained rabbits displayed decreased serum levels of hydroxyl radicals and malondialdehyde (MDA) (P 0.002). Notably, the trained group's ileum mucus' microbial populations had more homogeneity and aggregation. Our findings provided experimental and theoretical support for the use of Beta-glucan-induced trained immunity in preventing intestinal infection after weaning in rabbits. Pre-stimulation with Beta-glucan before weaning improved intestinal health by enhancing the immunity ability of both innate and adaptive immune in the newly weaned rabbits.


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How to Cite
Sujayaraj S, Smita Sarma, & S.K. Khatik. (2023). The Benefits of β-Glucan Injection during Suckling: Enhancing Immune Responses and Intestinal Health in Newly Weaned Rabbits. Revista Electronica De Veterinaria, 24(2), 366 - 377. Retrieved from