Solubility And Dissolution Rate Enhancement Of Fenoprofen By Binary And Ternary Phase Solid Dispersions.
Abstract
The purpose of this research was to increase the dissolution rate of Fenoprofen (FPN) by making solid dispersion systems (both binary and ternary) with different weight ratios of the active pharmaceutical ingredient (API), carrier, and surfactant. The binary and ternary solid dispersions were prepared by solvent and fusion methods. s. Binary solid dispersions of FPN were formed using polyethylene glycol 4000 (PEG 4000), and poloxamer 407. Tween 60 was added to create a ternary solid dispersion system. The optimal API-polymer weight ratio was determined to be 1:2. The addition of Tween 60 to the formulations prepared using the solvent method further improved the dissolution rate. Both binary and ternary solid dispersion systems demonstrated a significant enhancement in the dissolution of FPN. Solid dispersions containing poloxamer 407 exhibited higher solubility and faster dissolution profile, with the 1:2 API-polymer weight ratio identified as optimal.
References
2. Singh J, Walia M, Harikumar S. Solubility enhancement by solid dispersion method: a review. Journal of Drug Delivery and Therapeutics .2013 3(5):148-55.
3. Sharma A, Jain CP. Preparation and characterization of solid dispersions of carvedilol with PVP K30. Res Pharm Sci. 2010 Jan;5(1):49-56.
4. Nash, J F et al. “Linear pharmacokinetics of orally administered fenoprofen calcium.” Journal of pharmaceutical sciences vol. 68,9 (1979): 1087-90.
5. Koh PT, Chuah JN, Talekar M, Gorajana A, Garg S. Formulation development and dissolution rate enhancement of efavirenz by solid dispersion systems. Indian J Pharm Sci. 2013 May;75(3):291-301.
6. MV Srikanth, GV Murali Mohan Babu, SA Sunil, N Sreenivasa Rao, K Praveen Kumar, KV Ramana Murthy. Studies on the Effect of Hydrophilic Carriers in the Dissolution Rate Enhancement of Poorly Soluble API, Bicalutamide. Research J. Pharm. and Tech. 3(2): April- June 2010; Page 592-595.
